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机构地区:[1]苏州市广济医院,苏州215008 [2]中南大学湘雅二医院
出 处:《国际精神病学杂志》2012年第3期145-148,共4页Journal Of International Psychiatry
基 金:11.5"国家科技支撑课题"精神分裂症早期诊断技术与规范化治疗研究
摘 要:目的比较奥氮平、利培酮和阿立哌唑三种非典型抗精神病药对精神分裂症首次发作患者处理速度测验成绩的影响。方法 91例精神分裂症首发患者随机分配至阿立哌唑组(n=27)、利培酮组(n=37)和奥氮平组(n=27),在治疗前和治疗12周末完成如下测验:阳性与阴性症状量表、沟槽钉板测验、连线测验、Stroop色词测验、数字符号编码测验和范畴流利测验。结果 (1)治疗12周后,三组PANSS评分均较治疗前显著降低(P<0.001),三组间PANSS减分率的差异无统计学显著性;(2)奥氮平组治疗后的利手、连线A、颜色连线1、颜色连线2以及Stroop测验B得分均较治疗前显著改善(P<0.05~0.001);利培酮组治疗后的连线A、颜色连线1、颜色连线2、Stroop测验C以及数字符号编码得分均较治疗前显著改善(P<0.05~0.001);阿立哌唑组除颜色连线2外,其它各项评分的治疗前后比较差异无显著性(P>0.05)。结论在对首发精神分裂症患者的处理速度的改善方面,奥氮平和利培酮可能优于阿立哌唑。Objective To compare the efficacy of olanzapine,risperidone and aripiprazole on processing speed in patients with first-episode schizophrenia.Methods 91 first-episode patients with schizophrenia were randomized to olanzapine group(n=27),risperidone group(n=37) and aripiprazole group(n=27).All subjects were assessed with Positive and Negative Syndrome Scale(PANSS),Groove Pegboard Test(GPT),Trail Making Test(TMT),Stroop Color Word Test,Symbol Coding Test(SCT),Category Fluency Test(CFT).Results(1)Compared with the baseline,all the scores of PANSS decreased significantly(P〈0.001),but no significant difference of PANSS score change was found among the three groups(P〉0.05).(2)Compared with the baseline,the scores of Processing Speed improved significantly(P〈0.05~0.001) in the olanzapine group including Handedness,Line Test A,Color Line Test 1 and 2 and Stroop Test B.The change was found in the risperidone group including Line test A,Color line test 1 and 2,Stroop test C and digit symbolic coding.In the aripiprazole group,only the score of Color line test 2 improved significantly(P〈0.05).Conclusions The improvement on processing speed of olanzapine and risperidone would be probably better than aripiprazole.
关 键 词:非典型抗精神病药 精神分裂症 认知测验 处理速度
分 类 号:R749.3[医药卫生—神经病学与精神病学]
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