艾司西酞普兰治疗强迫症的疗效和对生活质量影响的对照研究  

Efficacy of Escitalopram and Influence on Quality of Life in Patients with Obsessive-compulsive Disorder

作　　者：姜文娟[1] 李轶琛[1] 冯少慧[1] 刘连忠[1] 周新芳[1] 

机构地区：[1]武汉市精神卫生中心,武汉430022

出　　处：《国际精神病学杂志》2012年第3期148-151,共4页Journal Of International Psychiatry

摘　　要：目的了解艾司西酞普兰治疗强迫症的有效性和对生活质量的影响;方法选择204例在武汉市精神卫生中心就诊的,根据CCMD-3诊断为强迫症的患者作为研究对象,分别应用艾司西酞普兰和氯丙咪嗪,通过24周的观察疗效和副反应,以及生活质量的变化。结果艾司西酞普兰治疗前后的自身对照表明治疗强迫症疗效显著。西酞普兰与氯米帕明在治疗八周前两者疗效无显著性差异,十周后艾司西酞普兰仍然持续改善强迫症状。且艾司西酞普兰的副作用和对于生活质量的提高均优于氯米帕明。结论艾司西酞普兰有助于强迫症病人提高长期疗效和生活质量的改善。Objective To explore the efficacy and the influence of escitalopram on quality of life in patients with obsessive-compulsive disorder.Method 204 patients with obsessive-compulsive disorder were treated by escitalopram and clomipramine.The efficacy and quality of life were measured with Yale-Brown obsessive-compulsive rating scale and general quality of life inventory-74（GQOLI-74） before and during the 24 weeks treatment.Results The efficacy of escitalopram is proved well.Compared with clomipramine,escitalopram had similar efficacy in the first 8 weeks treatment of obsessive-compulsive disorder while escitalopram had better efficacy from the 10th week,with fewer side effects all the time.Quality of life of patients was improved more in escitalopram group than in clomipramine group.Conclusion Escitalopram can improve the quality of life of obsessive compulsive disorder patients with better long-term efficacy.

关 键 词：艾司西酞普兰 强迫症 生活质量 

分 类 号：R749.3[医药卫生—神经病学与精神病学]