Cortical development and asymmetric cell divisions  

作　　者：Yan ZHOU 

机构地区：[1]College of Life Sciences, Wuhan University, Luojia Hill Wuhan 430072, China

出　　处：《Frontiers in Biology》2012年第4期297-306,共10页生物学前沿（英文版）

摘　　要：The development of the mammalian neocortex involves rounds of symmetric and asymmetric cell division of neural progenitors to fulfill needs of both self-renewal of progenitors and production of differentiated progenies such as neurons and glia. The machinery for asymmetric cell division is evolutionarily conserved and extensively used in organogeuesis and homeostasis of adult tissues. Here we summarize recent progress regarding cellular characteristics of different types of neural progenitors in mammals, highlighting how asymmetric cell division is utilized during cortical development.The development of the mammalian neocortex involves rounds of symmetric and asymmetric cell division of neural progenitors to fulfill needs of both self-renewal of progenitors and production of differentiated progenies such as neurons and glia. The machinery for asymmetric cell division is evolutionarily conserved and extensively used in organogeuesis and homeostasis of adult tissues. Here we summarize recent progress regarding cellular characteristics of different types of neural progenitors in mammals, highlighting how asymmetric cell division is utilized during cortical development.

关 键 词：asymmetric cell division radial glial cells CENTROSOME spindle orientation 

分 类 号：Q253[生物学—细胞生物学] S562[农业科学—作物学]