22例难治性癫痫患儿生酮饮食治疗前后的脑电图分析  

Analysis of electroencephalogram changes in 22 children with intractable epilepsy before and after ketogenic diet treatment

作　　者：费凌霞 李花 胡湘蜀 张伟 张佩琪 周锦华 

机构地区：[1]广东三九脑科医院癫痫诊疗中心,广东广州510515

出　　处：《癫痫与神经电生理学杂志》2012年第4期220-223,共4页Journal of Epileptology and Electroneurophysiology(China)

摘　　要：目的：观察难治性癫痫患儿生酮饮食（ketogenicdiet，KD）治疗前后脑电图（EEG）的变化。方法：观察KD临床疗效、起效时间，观察KD前及3个月后EEG背景及癫痫波的变化，评估EEG的变化与KD临床疗效、KD起效时间的关系。结果：KD能改善难治性癫痫患儿的EEG；部分对KD无效的患儿EEG也能改善；KD临床疗效和EEG的改善呈相关性。结论：KD能改善难治性癫痫患儿的EEG。Objective：To observe the electroencephatogram（EEG） changes for children with intractable epilepsy before and after three months＇ ketogenic diet （KD） therapy. Method：Our study was conducted by observing and analyzing the clinical effect of KD therapy and the starting time for patients responding to KD. At the same time EEG background and epilepsy waves before and after KD therapy were observed. Then the relations between EEG changes and clinical effect and the starting time for patients responding to KD were evaluated. Results：After KD,EEG of children with intractable epilepsy was markedly improved compared with those before KD therapy; the earlier the effect of KD appeared, the more marked EEG were improved. EEG was found improuved in some patients with no clinical efficacy of KD. Conclusion：KD can improve the EEGs of children with intractable epilepsy.

关 键 词：生酮饮食(KD) 难治性癫痫 脑电图(EEG) 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R741.044[医药卫生—临床医学]