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作 者:Juliana Ivanova Ivayla N. Pantcheva Rumyana Zhorova Georgi Momekov Svetlana Simova Radostina Stoyanova Ekaterina Zhecheva Simona Ivanova Mariana Mitewa
机构地区:[1].Faculty of Medicine, Sofia University, Sofia 1407, Bulgaria [2]Department of Analytical Chemistry, Faculty of Chemistry, Sofia University, Sofia 1164, Bulgaria [3]Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University-Sofia, Sofia 1000 Bulgaria [4]Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria [5]Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria
出 处:《Journal of Chemistry and Chemical Engineering》2012年第6期551-562,共12页化学与化工(英文版)
摘 要:SalNa (sodium salinomycin) reacts with divalent transition metal ions of Co(II), Ni(II), Cu(II) and Zn(II) to produce novel compounds characterized by various spectroscopic methods. The interaction of metal (II) ions with SalNa results in the formation of mononuclear complexes of a general composition of [M(Sal)2·(H2O)2] nH2O (n = 0 or 2) where the divalent cations replace Na~ ions from the cavity of initial compound. The new compounds (disalinomycinates) possess an enhanced antibacterial activity against Gram-positive microorganisms as compared to both SalNa and SalH (salinomycinic acid), respectively. The metal (II) complexes manifest strong concentration dependent cytotoxic effect in experiments using human leukemia cell lines. The complexes of Co0I) and Cu(lI) proved to exert superior activity as compared to the Ni(II) and Zn(II) analogues and are much more cytotoxic than SalNa and SalH. Further studies should be conducted to determine the therapeutic indexes of the new compounds.
关 键 词:SALINOMYCIN divalent metal complexes antibacterial properties antitumor activity.
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