SALINOMYCIN

作品数：12被引量：38H指数：4
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相关领域：医药卫生农业科学更多>>
相关作者：张杨贺智敏刘浩卢敏莹更多>>
相关机构：北京大学广州医科大学右江民族医学院南京农业大学更多>>
相关期刊：《Journal of Animal Science and Biotechnology》《Science China(Life Sciences)》《Acta Pharmacologica Sinica》《Science China Chemistry》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划更多>>
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Role of oregano and Citrus species-based essential oil preparation for the control of coccidiosis in broiler chickens被引量：7
《Journal of Animal Science and Biotechnology》2021年第3期1089-1097,共9页Francisco Xavier Gordillo Jaramillo Da-Hye Kim Sang Hyeok Lee Sun-Kwan Kwon Rajesh Jha Kyung-Woo Lee 
These studies were approved by the Institutional Animal Care and Use Committee of Konkuk University(Gwangjin-gu,Seoul,Republic of Korea,KU15186).
Background:Due to presence of drug-resistant Eimeria strains and raised public health safety concerns about drug residues in the meat,there is renewed interest in the search for natural alternatives to the coccidiosis...
关键词：Broiler chickens COCCIDIOSIS Essential oils Growth performance SALINOMYCIN 
Yi Qi Jie Du Formula and Salinomycin Combination Treatment Mediates Nasopharyngeal Carcinoma Stem Cell Proliferation,Migration and Apoptosis via CD44/Ras Signaling Pathway被引量：7
《Digital Chinese Medicine》2020年第4期297-308,共12页HE Lan ZHOU Fang-Liang ZOU Pan WANG Xian-Wen JIANG Yi-Lan HE Ying-Chun LIAO Duan-Fang CAO De-Liang 
We thank for the funding support from the National Natural Science Foundation of China(No.81874408,No.81973914 and No.81573721);the Natural Science Foundation of Hunan Province,China(No.2019JJ40216);Study Fundation of Hunan Provincial Education Department(No.19B439).
Objective To assess the effects of Yi Qi Jie Du Formula(YQJDF)combined with salinomycin(SAL)on nasopharyngeal carcinoma stem cells(NPC-SCs)and investigate the underlying molecular mechanisms.Methods Cell counting meth...
关键词：Yi Qi Jie Du Formula(YQJDF) SALINOMYCIN Nasopharyngeal carcinoma stem cells (NPC-SCs) PROLIFERATION Apoptosis CD44/Ras signaling pathway 
Enhancement of salinomycin production by ribosome engineering in Streptomyces albus被引量：9
《Science China(Life Sciences)》2019年第2期276-279,共4页Dong Li Jihui Zhang Yuqing Tian Huarong Tan 
supported by grants from the Ministry of Science and Technology of China (2015CB150600);the National Natural Science Foundation of China (31571281 and 31771378)
Dear Editor,Streptomyces can produce a large variety of secondary metabolites as a major source of anti-infective, antitumor or immune-suppressive agents widely applied in clinical treatment. Antibiotics-resistant bac...
关键词：ENHANCEMENT of SALINOMYCIN production by RIBOSOME ENGINEERING in STREPTOMYCES ALBUS 
A derivatization method to improve the assay of salinomycin sodium and its application in the liposomal formulation被引量：1
《Journal of Chinese Pharmaceutical Sciences》2018年第2期75-81,共7页Jingying Zhang Qian Luo Jiarui Xu Jing Bai Lei Liu Limin Mu Yan Yan Wanliang Lu 
National Science Foundation of China(Grant No.81673367)
Salinomycin sodium（SAL-Na） is a type of antibiotic chemotherapeutic drugs with the potential to treat cancer stem cells. The assay method of SAL-Na included in the pharmacopoeia is a microbiological method, which is...
关键词：Salinomycin sodium Vanillin derivatization UV-vis ASSAY Liposomes 
Salinomycin-loaded lipid-polymer nanoparticles with anti-CD20 aptamers selectively suppress human CD20＋ melanoma stem cells被引量：3
《Acta Pharmacologica Sinica》2018年第2期261-274,共14页Yi-bin ZENG Zuo-chong YU Yan-ni HE Tong ZHANG Ling-bo DU Yin-mei DONG Huai-wen CHEN Ying-ying ZHANG Wu-qing WANG 
This work was supported by 2017 Shanghai Minhang District Central Hospital Project （2017MHJC01）, Fudan University Affiliated Jinshan Hospital Excellent Youth Talent Training Program （2015-2）, Shanghai Jinshan District Health Family Planning System Excellent Youth Talent Training Program （JSYQ201605）, and the National Natural Science Foundation of China （81302363, 81771964, and 81602358）.
Melanoma is the deadliest type of skin cancer. CD20＋ melanoma stem cells （CSCs） are pivotal for metastasis and initiation of melanoma. Therefore, selective elimination of CD20＋ melanoma CSCs represents an effectiv...
关键词：MELANOMA cancer stem cells SALINOMYCIN nanoparticles CD20 aptamers 
Conversion of the high-yield salinomycin producer Streptomyces albus BK3-25 into a surrogate host for polyketide production被引量：3
《Science China(Life Sciences)》2017年第9期1000-1009,共10页Xiaojie Zhang Chenyang Lu Linquan Bai 
supported by grants from the National Natural Science Foundation of China(21661140002 and 31470157);the Ministry of Science and Technology of China(2012CB721005 and 2012AA022107)
An ideal surrogate host for heterologous production of various natural products is expected to have efficient nutrient utilization,fast growth,abundant precursors and energy supply,and a pronounced gene expression.Str...
关键词：surrogate host heterologous production POLYKETIDE SALINOMYCIN 
Effect of salinomycin on metastasis and invasion of bladder cancer cell line T24被引量：3
《Asian Pacific Journal of Tropical Medicine》2015年第7期575-578,共4页Hu Qu Bo Ma Hao-Feng Yuan Zhong-Yang Wang Sheng-Jie Guo Jing Zhang 
Objective: To explore the effect of salinomycin on the metastasis and invasion of bladder cancer cell line T24 by regulating the related protein expression in the process of epithelialmesenchymal transition(EMT), and ...
关键词：SALINOMYCIN BLADDER cancer METASTASIS and INVASION Epithelial-mesenchymal transition 
Salinomycin对乳腺癌阿霉素耐药细胞株MCF-7/DOX的增殖抑制作用及机制
《中国药理学通报》2015年第4期549-554,共6页刘浩 卢敏莹 贺智敏 
国家自然科学基金资助项目(No 81402497)
目的本研究旨在探讨Salinomycin对乳腺癌阿霉素耐药细胞株MCF-7/DOX增殖和凋亡的影响及可能作用机制。方法 MTS实验检测Salinomycin对MCF-7/DOX细胞增殖的影响;Annexin V-FITC/PI染色检测Salinomycin对MCF-7/DOX耐药细胞凋亡的影响;DCFH...
关键词：乳腺癌 SALINOMYCIN 阿霉素耐药 细胞凋亡 活性氧 线粒体膜电位 
Breeding of High-Yield Salinomycin-Producing Streptomyces albus Strains by Low Energy N^+ Ion Beam Irradiation
《Agricultural Biotechnology》2012年第5期55-56,F0003,共3页Liqin WU Fengxiang MIAO Haike GU Hongzhong SHANG 
[Objective] This study aimed to explore the mutagenesis effects of N＋ ion beam implantation on Streptomyces a/bus and obtain high-yield salinomycin- producing mutant strain. [ Method ] Streptomyces a/bus strain S-11-...
关键词：Streptomyces albus N ＋ ion beam irradiation SALINOMYCIN Mutation breeding 
Synthesis, Spectral Properties, Antibacterial and Antitumor Activity of Salinomycin Complexes with the Transition Metal Ions Co（ll）, Ni（ll）, Cu（ll） and Zn（ll）
《Journal of Chemistry and Chemical Engineering》2012年第6期551-562,共12页Juliana Ivanova Ivayla N. Pantcheva Rumyana Zhorova Georgi Momekov Svetlana Simova Radostina Stoyanova Ekaterina Zhecheva Simona Ivanova Mariana Mitewa 
SalNa （sodium salinomycin） reacts with divalent transition metal ions of Co（II）, Ni（II）, Cu（II） and Zn（II） to produce novel compounds characterized by various spectroscopic methods. The interaction of metal ...
关键词：SALINOMYCIN divalent metal complexes antibacterial properties antitumor activity. 
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