老年脑梗死患者血清性激素变化的临床研究  

Serum sex hormone changes in elderly patients with cerebral infarction

作　　者：张诚[1] 张子诚[1] 张向农[1] 

机构地区：[1]宿州市立医院干部病房神经二科,安徽宿州234000

出　　处：《中国性科学》2012年第8期16-18,21,共4页Chinese Journal of Human Sexuality

摘　　要：目的:分析老年脑梗死与血清性激素变化之间的关系,并探讨性激素引起脑梗死可能的机制。方法:选取2008年6月～2011年10月笔者所在医院收治的68例老年急性脑梗死患者作为研究对象,选择同期的58例健康体检者作为对照组。采用放射免疫法测定两组患者血清雌二醇、睾酮、催乳素和血清孕酮的水平,并将两组测定结果进行比较。结果:男性脑梗死组急性和恢复期患者E2、E2/Te水平均明显高于男性对照组(P>0.05),女性脑梗死组急性期和恢复期患者E2、Te均明显低于女性对照组(P>0.05),而E2/Te与对照组比较差异无统计学意义(P<0.05)。男女脑梗死患者急性期和恢复期的Pr、PRL与对照组比较差异均无统计学意义(P>0.05)。结论:男性E2、E2/Te水平升高,而女性E2水平降低,可能是引起脑梗死的危险因素之一。对患者血清性激素的研究有助于了解脑梗死的发病情况。Objectives： To analyze the relationship between cerebral infarction in elderly patients and serum sex hormone changes, and to explore the possible cerebral infarction mechanism caused by sex hormones. Methods： A total of 68 cases of eld- erly patients with acute cerebral infarction were selected for the study who were admitted into our hospital from June 2008 to Octo- ber 201. Another 58 healthy subjects were selected as the control group. The levels of estradiol, testosterone, prolactin, and ser- um progesterone of the two groups were measured by radioimmunoassay, and the results of the two groups were compared. Re- sults ： The levels of E2 and EJTe of male patients in cerebral infarction group were significantly higher as compared with the male control group（ P 〉 0. 05 ）. The levels of E2 and Te of the female patients in the cerebral infarction group were significantly lower than the levels in the female control group（ P 〉0. 05） , but the difference of E2/Te between the female cerebral infarction group and the control group had no statistical significance. Compared with the control group, the levels of Pr and PRL of male and fe- male patients with cerebral infarction in acute phase and recovery phase showed no significant difference （ P 〉 0. 05 ）. Conclu- sion： The high E2 and E2/Te level in men patients, and low E2 level in female patients may be the risk factors for cerebral infarc- tion. The study of sex hormones helps to understand the incidence of cerebral infarction.

关 键 词：脑梗死 血清性激素 变化 

分 类 号：R743.33[医药卫生—神经病学与精神病学]