肺癌中MTS1/p16和nm23基因产物的表达  

Expression of MTS1/p16 and nm23 Gene Products in Human Lung Cancer

作　　者：路名芝[1] 刘勇[1] 

机构地区：[1]江西省人民医院,江西南昌330006

出　　处：《浙江肿瘤》2000年第3期179-180,共2页

基　　金：江西省卫生厅科研基金资助课题!(980021)

摘　　要：[目的]探讨肺癌中MTS1/p16和nm3基因产物的表达意义。[方法]应用SP免疫组织化学方法研究62例肺癌组织中p16蛋白和nm23蛋白的表达情况。[结果]62例肺癌组织中p16蛋白和nm23蛋白阳性率分别为58 1 %和48 4%。腺癌p16蛋白的阳性率明显高于小细胞癌(P<0 05) ;淋巴结转移阳性组p16蛋白的表达显著低于阴性组(P<0 05 ,r=0 27)。不同组织类型肺癌中nm23蛋白的表达未见明显差异 ,淋巴结转移阳性组nm23蛋白的表达低于阴性组(P<0 01 ,r=0 52)。p16蛋白和nm23蛋白的表达之间未见明显相关。[结论]提示p16蛋白的表达与肺癌的组织学类型有关 ,nm23蛋白低表达对肺癌细胞的淋巴结转移起重要作用。检测nm23蛋白的表达可作为判断肺癌淋巴结转移的一项新指标。To study the expressions of MTS1/p16 and nm23 gene products in human lung cancerThe expressions of p16 and nm23 protein in 62 cases lung carcinoma were measured by SP immunohistochemical methodsThe positive expression rates for p16 and nm23 protein were 581% and 484% respectivelyA significant correlation was found between lownm23 protein expression and lymph node metastasis(P<001)No significant correlation between the expression of p16 and nm23 protein was found[Conclusions]The results suggest that lownm23 protein expression plays an important role in metastasis of lung cancer

关 键 词：肺肿瘤 淋巴结转移 P16 NM23 免疫组织化学 

分 类 号：R734.202[医药卫生—肿瘤]