P27蛋白和Ki-67抗原在人脑星形细胞肿瘤中的表达及其意义  

Expression and significance of P27 protein and Ki-67 antigen in astrocytic tumors

作　　者：刁宏宇[1] 潘德生[1] 胡升 潘蔚然[1] 王成林[1] 赵崇智[1] 

机构地区：[1]中国医科大学附属第二医院神经外科,沈阳110003 [2]朝阳市第二人民医院神经外科

出　　处：《中华神经外科杂志》2000年第4期229-231,共3页Chinese Journal of Neurosurgery

摘　　要：目的　研究P2 7蛋白及Ki 6 7抗原在人脑星形细胞肿瘤中的表达情况以及它们之间的相互关系。方法　S P免疫组化方法。结果　 (1)P2 7在星形细胞肿瘤中的表达程度 (LImean =2 7 4% )显著低于非肿瘤脑组织 (LImean =6 8 8% ) ,而且其表达强度随肿瘤恶性程度增高而下降。(2 )P2 7与Ki 6 7的表达呈显著负相关 (r = 0 86 ,P <0 0 1)。结论　P2 7蛋白表达的缺失可能与脑星形细胞肿瘤的发生有密切关系 。Objective To detect the expression of P27 protein and Ki 67 antigen in astrocytic tumors.Methods S P immunohistochemical analysis was used. Results (1) The expression of P27 in astrocytic tumors (LI mean=27 4%) was remarkablely weaker than that in non tumor brain tissues (LI mean=68 8%). The intensify of P27 staining was stronger in tumors with lower grade of malignancy. (2) In astrocytic tumors, a significant negative correlation (r=-0 86, P<0 01) is observed between the P27 and Ki 67 labeling indexes(LI). Conclusions The decreased P27 protein expression might play a important role in the genesis and development of astrocytic tumors. Immunohistochemical analysis of P27 might be useful in deciding the grade of malignancy of astrocytic tumors.

关 键 词：P27蛋白 KI-67抗原 星形细胞肿瘤 脑肿瘤 

分 类 号：R739.41[医药卫生—肿瘤]