三维彩色血管能量成像鉴别乳腺肿瘤良恶性的应用价值  

Value of three-dimensional color power angiography in the differential diagnosis of benign and malignant breast tumors

作　　者：周南[1] 张海[2] 孙枫[2] 彭启慧[2] 刘仕龙[2] 牟赛辉[2] 

机构地区：[1]湖南省株洲市一医院功能科,412000 [2]深圳市人民医院暨南大学第二临床医学院超声科

出　　处：《中华超声影像学杂志》2012年第8期698-700,共3页Chinese Journal of Ultrasonography

基　　金：2010年广东省科技计划项目（2010B031100014）

摘　　要：目的探讨三维彩色血管能量成像在鉴别诊断乳腺肿瘤良恶性中的应用价值。方法对114例女性患者共121个乳腺实质性肿块进行三维彩色血管能量成像检查（恶性组63个，良性组58个），并对血管血流等参数进行分析，应用受试者工作特征（ROC）曲线比较各项参数的诊断价值。结果与良性组相比，恶性组肿块内血流指数（FI1）、包含肿块周边3mm组织的血流指数（FI2）及上述两种参数的比值G2（FI2／FI4）在两组间差异有统计学意义（P均〈0．05）。FI2的ROC曲线下面积最大，FI2与G2曲线下面积比较差异无统计学意义（P〉0．05），FI2与FI1曲线下面积比较差异有统计学意义（P〈0．05）。以FI2≥27．385作为临界值，诊断乳腺恶性肿瘤的敏感性为88．9％，特异性为81.0％，阳性预测值为83．6％，阴性预测值为87．0％。结论三维彩色能量成像参数FI2诊断乳腺恶性肿瘤的特异性和敏感性较高；FI2的最佳临界点为≥27．385，有助于乳腺良恶性肿瘤的鉴别诊断。Objective To evaluate the value of three-dimensional color power angiography（3D-CPA） in the differential diagnosis of benign and malignant breast tumors. Methods 3D-CPA vascular parameters were collected and analyzed in 121 breast solid lesions （63 malignant,58 benign） in the 114 female patients. The diagnostic performances of each parameter were compared by receiver operating characteristic （ROC） cure. Results The parameters of intra-tumor flow index （FI1） ,flow index of shells with outside thickness of 3mm surrounding the breast tumors（FI2） and the ratio of FI2 and FI1 （G2） in malignant group were significantly higher than those in benign group（ P 〈0.05, respectively）. Analysis of the areas under ROC curve showed that the areas under FI2 curve was the largest. No significant difference（ P 〉0.05） was found between the area under FI2 curve and the area under G2 curve. Comparing the area under FI2 curve to that under FI1, there was significant differences （P 〈 0. 05）. Taking FI2≥27. 385 as the critical value, the sensitivity and specificity for the diagnosis of malignant breast tumors were 88.9% and 81. 0%, and the positive and negative predictive values were 83.6% and 87.0% respectively. Conclusions The sensitivity and specificity of 3D-CPA parameter FI2 in the diagnosis of malignant breast tumors were higher than others. FI2 with the optimal critical value of 927. 385 could help to identify malignant from benign breast tumors.

关 键 词：超声检查 乳腺肿瘤 诊断 鉴别 三维彩色血管能量成像 

分 类 号：R737.9[医药卫生—肿瘤]