Hedgehog信号通路与乳腺癌  

Hedgehog Signal Pathway in the Breast Cancer

作　　者：屈超[1] 陈茜[1] 黄慧芳[1] 崔玉影[1] 邹伟[1,2] 

机构地区：[1]辽宁师范大学生命科学学院,辽宁大连116081 [2]辽宁省生物技术与分子药物研发重点实验室,辽宁大连116081

出　　处：《生物技术通讯》2012年第4期604-605,共2页Letters in Biotechnology

基　　金：国家自然科学基金(30570225)

摘　　要：近年来的研究表明,Hedgehog信号通路在肿瘤的发生发展中具有重要的作用,该通路基因突变或异常表达将导致多种器官肿瘤的发生,并与Wnt、MAPK等信号通路相互作用,共同调节肿瘤的发生发展。我们简要综述了Hedgehog信号通路在乳腺癌发生发展中的重要作用,旨在了解乳腺癌发生、发展的分子机制.The Hedgehog signaling pathway is considered to be involved in the molecular mechanism of the invasion and metastasis of the tumors. Mutations or abnormal expression in components of this pathway lead to the growth of breast tumors. Hedgehog signaling pathway interacts with Wnt, MAPK to regulate the progress of tumors. To better understand the molecular mechanism on the growth and progress of breast cancer, the vital role of Hedgehog signaling pathway on the growth and development of breast cancers was briefly reviewed.

关 键 词：乳腺癌 HEDGEHOG信号通路 WNT MAPK 

分 类 号：Q257[生物学—细胞生物学] R737.9[医药卫生—肿瘤]