水相中铜催化含氮杂环化合物的N-芳基化反应  

Copper-Catalyzed N-Arylations of Nitrogen-Containing Heterocycles in Water

作　　者：张敬先[1] 殷慧清[1] 韩世清[1] 

机构地区：[1]南京工业大学生物与制药工程学院,南京211816

出　　处：《有机化学》2012年第8期1429-1433,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.20942006;21072095)资助项目~~

摘　　要：在水相中建立了一种简单实用、经济环保的实现含氮杂环化合物N-芳基化反应的催化体系.实验发现以廉价的Cu2O为催化剂,价廉、易获得的8-羟基喹啉为配体,n-Bu4NBr为相转移催化剂,在水相中100℃下含氮杂环化合物与卤代芳烃顺利反应生成C—N偶联产物,得到中等及优良的产率.A simple,efficient,inexpensive and powerful method for the C—N coupling of nitrogen-containing heterocycles with aryl halides was developed by using cheap Cu2O as catalyst,inexpensive and readily available 8-hydroxyquinoline as ligand,n-Bu4NBr as phase transfer catalyst,water as solvent at 100 ℃.Most products were synthesized in good to excellent yields.

关 键 词：铜催化 氮杂环化合物 N-芳基化 水相 

分 类 号：O643.32[理学—物理化学]