小金丸加减为主治疗中晚期胃癌术后患者疗效观察  

Curative Effects of Modified Xiao-Jin Pills(小金丸)and Chemical Treatment after Operation in Patients with Mid and Late Phase of Gastric Cancer

作　　者：周阿高[1] 丁钰熊[1] 陈梅芳[1] 黄大慰[2] 李德华[2] 江绍基[2] 

机构地区：[1]上海第二医科大学中医学教研室,上海200025 [2]上海第二医科大学附属仁济医院

出　　处：《中西医结合杂志》1990年第6期343-344,共2页

摘　　要：运用小金丸加减为主治疗中晚期胃癌(术后)患者44例,并与对照组28例进行对比观察,取得了较好的近期疗效。结果显示,小金丸加减能明显提高胃癌患者1年,2年生存率( P均<0.05);降低紫舌阳性率(P<0.001);改善 AT-Ⅲ.Fn、Fa 和ⅧR:Ag 等血凝指标(P 均<0.05)。说明该方能增强机体抗凝-纤溶能力,改善血瘀状态,提高生存率。From 1986,the authors mainly used Modified Xiao-Jin Pills (MXJP) added with chemical treatment to cure patients in mid and late phase of gastric cancer after operation.72 patients were verified as gastric cancer by pathological section and phases were divided according to TNM classification which was revised by the national cooperative group of gastric cancer in 1978.The patients were randomly divided into curative and control groups.The two groups were basically similar in sex,age,clinic pathological phase and operation.One month after operation,the two groups received the same treatment except that the control group did not take MXJP.The indexes of observation consisted of living rate,substance of tongue and 5 indexes of blood coagulation (AT- Ⅲ,Fn,FA,Ⅷ R:Ag and βTG).The curative effects showed that MXJP could enhance gastric cancer patients' living rate for 1,1.5 and 2 years among which it was obvious for phase IV's gastric cancer patients to enhance 1 year's living rate (P<0.05),and lower the negative rate of substance of tongue (P<0.001).The indexes of AT-Ⅲ,Fn FA and Ⅷ R:Ag and βTG of gastric cancer patients had changed for the better (P<0.05).The results showed that MXJP can enhance the capacity of body to antagonize coagulation fibrinolysis,remove blood stasis and further enhance the living rate of patients.MXJP has better curative effects of short term.

关 键 词：小金丸 胃癌 紫舌阳性率 生存率 

分 类 号：R735.205[医药卫生—肿瘤]