B7-H4基因在直肠癌组织的表达及其临床意义  

Study on expression and the significance of B7-H4 in rectal carcinoma

作　　者：梁群英[1] 冯爱菊[1] 张玉文[1] 邱晓娣[1] 窦颖[1] 

机构地区：[1]河南省商丘市第一人民医院病理科,476100

出　　处：《中国医药》2012年第9期1131-1132,共2页China Medicine

摘　　要：目的研究B7-H4基因在直肠癌组织中的表达及其临床意义。方法采用免疫组织化学sP法检测B7-H4基凶分子在65例直肠癌组织中的表达水平。结果B7-H4基因在直肠癌组织中表达阳性率为78．5％（51／65）；B7-H4基因的阳性表达与直肠癌患者的性别、年龄、肿瘤大小无关（P〉0．05），而与肿瘤分期和有无淋巴结转移相关（P〈0．05）；B7-H4基因阳性表达的直肠癌患者平均生存时间明显短于阴性表达患者[（36±7）个月比（48±9）个月，P〈0．05]。结论B7-H4基因在直肠癌组织的过表达，町能为直肠癌新的具有诊断价值的肿瘤标志物，可作为直肠癌患者预后不良的参考指标。Objective To explore the expression of BT-H4 in rectal carcinoma and the relationship between its expression and the clinicopathological features. Methods The expression of B7-H4 was detected by immunohistochemistry in 65 patients with rectal carcinomas. Results The positive rate of BT-H4 in cases of rectal carcinomas was 78.5% （51/65） , which was apparently higher than that of normal rectal mucosa epitheliums （P 〈 0. 05 ）. The expression of B7-H4 in patients with rectal carcinomas was closely correlated with stage and lymph node metastasis, but was irrelevant to sex, age and tumor size. The mean survival time in patients with positive expression of BT-H4 was significantly shorter than that of cases with negative expression. Conclusion The overexpression of B7-H4 might be involved in the onset and progression of rectal carcinoma and an be a reference index of poor prognosis in rectal carcinoma.

关 键 词：直肠肿瘤 基因 肿瘤 B7-H4 免疫组织化学 预后 

分 类 号：R735.3[医药卫生—肿瘤]