小儿炎性肌纤维母细胞瘤诊断与治疗的探讨  

Diagnosis and treatment of inflammatory myofibroblastic tumors in children

作　　者：刘菁[1] 张晓伦[1] 包楠[1] 邹继珍[1] 袁新宇[1] 郝春生[1] 叶辉[1] 

机构地区：[1]首都儿科研究所附属儿童医院,北京100020

出　　处：《中国小儿血液与肿瘤杂志》2012年第4期169-173,共5页Journal of China Pediatric Blood and Cancer

摘　　要：目的探讨小儿炎性肌纤维母细胞瘤(IMT)的诊断与治疗方法。方法分析和总结我院收治的5例手术病理确诊为IMT患儿的临床表现、实验室检查、影像学检查、病理学诊断、外科治疗方法及随访情况等。结果 5例IMT患儿中,2例肿瘤位于膀胱,3例肿瘤分别位于颈部、腹部及右下肺,行肿瘤完整切除术,其中膀胱及右下肺肿瘤患儿术后随访2～8个月未见肿瘤复发,腹部肿瘤患儿未能随访;1例膀胱肿瘤活检,明确诊断后家长放弃治疗;1例颈部肿瘤复发,初期经化疗肿瘤消失,后出现颈部肿瘤转移及复发,再次手术及化疗,后期无法有效控制肿瘤增长,最终家长放弃治疗。结论小儿IMT是一种罕见的软组织肿瘤,无特异性表现,确诊依靠病理学检查。手术切除是有效的治疗方法,但存在复发和转移可能,术后需长期随访,对于复发者化疗有一定疗效,反复复发者预后不良。Objective To investigate the diagnosis and treatment of inflammatory myofibroblastic tumors （IMT） in children. Methods Five cases with IMT in our department from the May of 2006 to the June of 2010 were reviewed retrospectively. Results the other 3 cases had tumors in neck, abdomen and lung resection; one case with tumor in bladder gave up treatment Among the 5 cases, 2 had tumors in bladder, respectively. Three cases received tumor complete after biopsy; one case with recurrent tumor in neck gave up treatment after tumor resection twice and failure of chemotherapy. Conclusion Inflammatory myofibroblastic tumor in children is rarely occurred. The diagnosis relies on the pathology and immunohistologic analysis. Surgery is an effective treatment but with the high risk of relapse and metastasis. Long-term follow-up after surgery is necessary. The prognosis of recurrent case is poor even with chemotherapy.

关 键 词：炎性肌纤维母细胞瘤 小儿 

分 类 号：R738[医药卫生—肿瘤]