Periostin与血管支架内再狭窄关系的研究进展  

Progress in the study on relationship between periostin and reangiostenosis

作　　者：魏本[1] 郭富强[2] 

机构地区：[1]泸州医学院临床学院,四川泸州646000 [2]四川省医学科学院四川省人民医院神经内科,四川成都610072

出　　处：《川北医学院学报》2012年第4期313-317,共5页Journal of North Sichuan Medical College

基　　金：四川省科技厅科技支撑项目(2009FZ0080)

摘　　要：Periostin是一种近年发现的分泌型可溶解性细胞间基质蛋白,可促进血管平滑肌细胞增殖并合成基质蛋白,导致新生内膜的形成,进而使损伤血管的管腔变小。血管再狭窄是血管成形术及支架置入术的主要不良反应之一,其以新生内膜形成为特征,是一个涉及多种能分泌细胞因子及生长因子的细胞参与并引起血管局部炎症反应和增殖的病理过程。Periostin参与血管支架内再狭窄的形成可能与平滑肌细胞相互作用以及其它机制有关,其分子机制需进一步研究。Periostin has reoently been found as a kind of secretion type which can dissolve between cell matrix proteins. It can pro- mote vascular smooth muscle cell proliferation and synthetize matrix proteinsleading to the formation of ueointimal thus lessening the damage toblood vessels lumens. Reangiostenosis is one of major adverse reaction angioplasty or with internal stents, and marked by neointimal formation. It is a kind of the pathological process which is involved with several secreted cell factors and growih factors in the cells. This causeslocal inflammatory reactions and proliferation in the blood vessels. Periostin may be related to reangiostenosis through the interaction with smooth muscle cells and other mechanisms. However, due to the limited research of this aspect,the specific molecu- lar mechanism is still not very clear. Therefore, more and more in-depth research is needed for it to be clarified.

关 键 词：PERIOSTIN 血管内再狭窄 血管内支架置入术 血管成形术 

分 类 号：R363[医药卫生—病理学]