溃疡性结肠炎患者P-选择素和血小板参数分析  

Analysis of P-selectin and Platelet Parameters in Patients with Ulcerative Colitis

作　　者：黄勤[1] 王恩[2] 林敏华[1] 颜小丹[1] 张玉[1] 

机构地区：[1]浙江省台州医院消化内科,317000 [2]浙江省台州医院神经内科,317000

出　　处：《胃肠病学》2012年第7期430-432,共3页Chinese Journal of Gastroenterology

摘　　要：背景:研究发现凝血机制活化在炎症性肠病(IBD)的进展过程中起重要作用。P-选择素(CD62P)参与介导凝血和炎症反应时中性粒细胞和单核细胞与活化的血小板或内皮细胞的黏附。目的:探讨血小板活化标记物P-选择素以及血小板计数(PLT)、平均血小板体积(MPV)用于溃疡性结肠炎(UC)疾病活动度评估的价值。方法:纳入65例活动期UC患者、31例缓解期UC患者和60例健康对照者。流式细胞术测定外周血P-选择素阳性率,血细胞分析仪测定PLT、MPV,分析三者与UC活动度的相关性。结果:UC患者外周血CD62P阳性率、PLT显著高于对照组(P<0.01),MPV显著低于对照组(P<0.01);活动期UC患者三项指标的变化均较缓解期UC患者更为显著,组间差异有统计学意义(P<0.05)。外周血CD62P、PLT与UC活动度呈正相关(P<0.05),MPV与UC活动度呈负相关(P<0.05)。结论:UC患者的机体处于高凝状态。P-选择素、PLT、MPV能反映UC疾病活动度,对病情评估和治疗方案的制定有一定参考价值。Background： It was demonstrated that activation of coagulation contributed to the progression of inflammatory bowel disease （IBD）. P-selectin （CD26P） is thought to mediate the adhesion of neutrophils and monocytes with activated platelets or endothelial cells in hemostasis and inflammatory response. Ahns： To explore the value of P-selectin, a marker of platelet activation, as well as platelet count （PLT） and mean platelet volume （MPV） in assessment of disease activity in ulcerative colitis （UC）. Methods： A total of 96 UC patients, including 65 active UC and 31 inactive UC were enrolled; 60 healthy subjects served as controls. Peripheral P-selectin positivity rate was determined by flow cytometry, and PLT and MPV were measured by whole blood analyzer. Correlations of P-selectin, PLT and MPV with UC disease activity were analyzed. Results： Peripheral CD62P positivity rate and PLT were significantly higher and MPV was significantly lower in UC patients than in healthy controls （P 〈 0.01 ）. Changes of CD62P, PLT and MPV were more significant in active UC than in inactive UC （ P 〈 0.05 ）. Positive correlations were observed between peripheral CD62P, PLT and UC disease activity （ P 〈 0.05 ）, while negative correlation was observed between MPV and UC disease activity （ P 〈 0.05 ）. Conclusions： A hypercoagulable state is present in UC patients. P-selectin, PLT and MPV are correlated with disease activity of UC, and might be used as references for assessment of disease activity and decision of therapeutic regimen in UC.

关 键 词：结肠炎 溃疡性 P选择素 血小板计数 平均血小板体积 

分 类 号：R574.62[医药卫生—消化系统]