左乙拉西坦治疗新诊断癫癎120例  

Curative Effect of Levetiracctam Monotherapy on Newly Diagnosed Epilepsy Patients

作　　者：杨春清[1] 李哲[1] 李攀[1] 李文玲[1] 崔雪花[1] 杜亚丽[1] 

机构地区：[1]河北省人民医院癫癎中心,石家庄050051

出　　处：《医药导报》2012年第8期1017-1020,共4页Herald of Medicine

基　　金：河北省卫生厅基金项目(20100003)

摘　　要：目的探讨左乙拉西坦(LEV)对新诊断癫癎患者的临床疗效,以及对癫癎患者脑电活动的影响。方法LEV单药治疗新诊断的癫癎患者120例,进行开放性自身对照随访研究。成人初始剂量每次0.5 g,bid,po,2周后增至每次1.0 g,bid,4周后加量至每次1.5 g,bid;儿童初始剂量10 mg·kg-1·d-1,以后每周增加10 mg·kg-1·d-1,3～4周增加至目标剂量(20～40 mg·kg-1·d-1),每天分两次服药。观察治疗后2,6,12个月临床疗效、发作间期癎样放电(IEA)、脑电背景活动情况。结果治疗后2,6,12个月总有效率分别为89.2%,82.5%,77.5%;IEA消失或减少>50.0%分别为48.3%,50.0%及52.5%。治疗6个月后脑电地形图θ、δ频段相对功率较治疗前降低,α频段相对功率增加,β频段相对功率无明显变化。结论 LEV对新诊断癫癎发作有较好疗效,安全性好,可使癎样放电减少或消失,且能改善脑电背景活动。Objective To investigate the therapeutic effect of levetiractam （LEV） on electroencephalogram of epileptic patients. Methods In this open-label self-control study, 120 newly diagnosed epileptic patients received LEV monotherapy. The patients were followed up for therapeutic effect, interictal epileptiform activity （IEA） and electroencephalogram （EEG） background activity two months, six months or twelve months after the therapy. Results After two months, six months, and twelve months LEV therapy, the total effective rates were 89.2% , 82.5% and 77.5%, and IEA was vanished or decreased 〉 50% in 48.3% , 50.0% and 52.5% cases, respectively. After six months LEV therapy, the relative power of 0, 8 band significantly decreased （P〈0.05）, the relative power of a band increased, and that of 13 band did not change by brain electrical activity mapping. Conclusion LEV monotherapy is effective for newly diagnosed epilepsy with various seizures, and can diminish or even vanish IEA and improve EEG background activity.

关 键 词：左乙拉西坦 癫癎 癎样放电 脑电图 

分 类 号：R741[医药卫生—神经病学与精神病学] R971[医药卫生—临床医学]