门脉高压性胃病患者胃黏膜中ET-1与HIF-1的表达及其意义  

Expression and significance of endothelin-1and hypoxia inducible factor-1in gastric mucosa of patients with portal hypertensive gastropathy

作　　者：陈吉[1] 崔宏[1] 王茂林[1] 贺亚妮[1] 

机构地区：[1]内蒙古医学院第三临床医学院消化内科,包头市014010

出　　处：《国际消化病杂志》2012年第4期244-246,共3页International Journal of Digestive Diseases

摘　　要：目的探讨门脉高压性胃病(PHG)患者胃黏膜中内皮素-1(ET-1)和缺氧诱导因子-1(HIF-1)的表达及其相关性,为PHG的发病机制提供一定理论依据。方法随机选择从2010年11月至2011年6月期间的PHG患者60例、门静脉高压症(PHT)无PHG患者30例和正常对照者20例,PHG组中分为轻型34例、重型26例。经胃镜取胃黏膜,采用免疫组化方法检测ET-1蛋白和HIF-1蛋白的含量。结果 PHG组和PHT无PHG组的ET-1、HIF-1表达均较正常对照组增强,差异有统计学意义(P<0.05)。PHG组中重型患者的ET-1表达较轻型增强,差异无统计学意义(P>0.05),PHG组重型患者的HIF-1表达较轻型增强,差异有统计学意义(P<0.05)。结论 ET-1、HIF-1可能参与PHG的发病过程,与胃黏膜病理损害有关。Objective To discuss the expression of endothelin 1 （ET-1） and hypoxia inducible factor-1 （HIF-1） in gastric mucosa of portal hypertensive gastropathy （PHG） patients, and the internal relations between them, to provide theoretical proof for the pathogenesis of PHG. Methods Patients were selected and divided into PHG （60 cases）, PHT without PHG （30 cases）, and healthy controls（20 cases） from November 2010 to June 2011. The PHG group was categoried as moderate and severe. Detected the level of ET-1 protein and HIF1 protein in gastric mucosa by immunohistochemical methods. Results Compared with healthy control group, ET-1, HIF-I in the PHT without PHG group and PHG group were increased, there were significant difference （P〈0.05）. The expression of ET-1 in the PHG of severe was more than in the PHG of moderate, there was no significant difference （P〉0.05）. The expression of HIF 1 in the PHG of severe was more than in the PHG of moderate, there was significant difference （P〈0.05）. Conclusion ET-1, HIF-1 may be involved in the pathogenesis of PHG, and damaged to the gastric pathology.

关 键 词：门脉高压性胃病 内皮素-1 缺氧诱导因子-1 

分 类 号：R575.2[医药卫生—消化系统]