中青年症状性动脉粥样硬化性颅内动脉狭窄患者中LDL-C/HDL-C比值分析  

Analysis on LDL-C/HDL-C Ratio of Young and Middle-aged Patients with Symptomatic Intracranial Atherosclerotic Stenosis

作　　者：伍明[1] 范学军[2] 李梅笑[1] 蒙巍[1] 王扬[1] 吴珊[1] 

机构地区：[1]深圳市龙岗区人民医院神经内科,广东深圳518172 [2]中南大学湘雅三医院神经内科

出　　处：《实用预防医学》2012年第8期1253-1256,共4页Practical Preventive Medicine

摘　　要：目的探讨LDL-C/HDL-C比值在中青年症状性动脉粥样硬化性颅内动脉狭窄(sICAS)发病机制中的意义。方法通过NIHSS评分对37例中青年sICAS新发患者分成两病例组,同时收集同期住院中青年头晕患者40例作为对照组,分析病例组和对照组LDL-C/HDL-C比值差异。治疗6个月后再次分析病例组血管病变、LDL-C/HDL-C比值前后对比情况。结果中青年sICAS患者LDL-C/HDL-C比值增大,与对照组比较差异有统计学意义;通过治疗后,研究组中64.71%的颅内血管狭窄好转,LDL-C/HDL-C比值变小,前后比较差异有统计学意义。结论 LDL-C/HDL-C比值增大是中青年sICAS重要的危险因素;拜阿司匹林联合阿托伐他汀干预能降低LDL-C/HDL-C比值,缓解中青年sICAS。Objective To explore the significance of LDL - C/HDL - C ratio in the pathogenesis of symptomatic intracra- nial atherosclerotic stenosis （sICAS） among young and middle- aged patients. Methods According to the NIHSS scores, 37 young and middle- aged patients with newly- diagnosed sICAS were divided into two case- groups. Meanwhile, 40 young and middle - aged patients with dizziness were selected as control group. The differences of LDL - C/HDL - C ratio between case - groups and control group were analyzed. After 6 - month treatment, vascular lesions and LDL - C/HDL- C ratio were analyzed again, and then compared with the data collected prior to the treatment. Results As compared with normal controls, lower HDL - C value and increased LDL - C/HDL- C ratio were observed in young and middle - aged patients with sICAS. The differ- ences between case- groups and control group were statistically significant. As compared with the condition before the treatment, 64.71% of case - groups showed improved intracranial vascular stenosis and decreased LDL - C/HI）L - c ratio upon treatment. The difference between before and after the treatment was also statistically significant. Conclusions Increased LDL- C/HDL - c ratio is an important risk factor for young and middle - aged patients with sICAS. Aspirin plus atorvastatin combined therapy can decrease LDL - C/HDL- c ratio and improve sICAS in young and middle - aged patients.

关 键 词：中青年 颅内动脉狭窄 低密度脂蛋白胆固醇 高密度脂蛋白胆固醇 磁共振血管成像 

分 类 号：R743[医药卫生—神经病学与精神病学]