右旋龙脑-β-环糊精包合物稳定性和溶出度的研究  

Study on stability and dissolution of inclusion complex of D-borneol with β-cyclodextrin

作　　者：苏健裕[1] 陈建平[1] 李冰[1] 李琳[1] 

机构地区：[1]华南理工大学轻工与食品学院,广州510640

出　　处：《中华中医药杂志》2012年第8期2196-2199,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：广东省自然科学基金博士启动项目(No.10451064101005160);省部产学研结合项目(No.2009A090100041;No.2010B090500033);中央高校基本科研业务费专项资金(No.2011ZM0099)~~

摘　　要：目的:对右旋龙脑-β-环糊精包合物的稳定性和溶出速率进行考察。方法:采用气相色谱法,以右旋龙脑含量测定为指标,分别对右旋龙脑-β-环糊精包合物和混合物进行挥发性试验、热稳定性试验、抗光解试验和溶出度试验。结果:在光和热的影响下,包合物中右旋龙脑的挥发速率要明显小于混合物。溶出度实验表明,包合物的溶出速率明显快于混合物。结论:右旋龙脑被包合后,其稳定性明显优于单纯的右旋龙脑,便于长久贮存而不改变疗效。并且右旋龙被包合后,其体外溶出速率有显著的提高,便于发挥其药效。Objective：To study the stability and dissolution of inclusion complex of D-borneol with β-cyclodextrin.Methods：Through the volatility test,thermal stability test,anti-photodecomposition test and dissolution test,the stability and dissolution of D-borneol-β-cyclodextrin inclusion complex and physical mixture was studied by determining the changes of D-borneol contents by gas chromatography（GC）.Results：Under the influences of light and heat,the volatile rate of D-borneol of inclusion complex was slower than physical mixture.Meanwhile,the dissolution rate of inclusion complex was faster than physical mixture.Conclusion：D-borenol-β-cyclodextrin inclusion complex had certain anti-photodissociation and thermal stability and was more stable than D-borneol alone.It could be stored longer without changing therapeutic effect.And in vitro dissolution rate of inclusion complex was improved significantly.

关 键 词：右旋龙脑 Β-环糊精 包合物 稳定性 溶出度 

分 类 号：R943[医药卫生—药剂学]