宫颈浸润癌组织中CD44V6、PCNA、CⅣ表达与转移潜能的关系研究  

Expression of CD44V6、PCNA、CⅣ in Cervical Invasion Cancer and Metastasis Potentiality

作　　者：王冬[1] 王占东[2] 安晓汾[1] 

机构地区：[1]第四军医大学吉林军医学院附属医院妇产科,132011 [2]白求恩医科大学第二临床学院妇产科,130000

出　　处：《实用癌症杂志》2000年第4期388-390,共3页The Practical Journal of Cancer

摘　　要：目的　探讨CD44V 6、PCNA、CⅣ在宫颈浸润癌组织中的表达与转移潜能的关系。方法　采用免疫组织化学S P法检测 10 4例宫颈浸润癌组织中的CD44V 6、PCNA、CⅣ单克隆抗体表达情况。结果　正常组织对CD44V 6不表达 ;有淋巴结转移的宫颈癌组织对CD44V 6呈过表达 ,阳性率为 81.6% ,无淋巴结转移的宫颈癌组织对CD44V 6呈低表达 ,阳性率为 3 6.4% ;CD44V 6阳性表达组伴有PCNA过表达和CⅣ低表达 ,与CD 44V 6阴性表达组比较有显著性差异。结论　CD 44V 6与肿瘤淋巴结转移有关 ,CD44V 6阳性表达组织可能具有转移潜能。Objective To study expression of CD44V6、PCNA、CⅣ in the cervical invasion cancer and their metastasis potentiality.Methods Expression of CD44V6、PCNA、CⅣ in 104 case of cervical cancer were detected by immunohistochemistry S P method.Results In normal cervical tissues,there were not expression of CD44V6.In pelvie lympy node metastasis groups,CD44V6 was expressed with a high positive rate of 81.57%.In the group without pelvie lympy node metastasis,a lower positive rate of 36.36% was found.It was significant different between the two groups.In CD44V6 positive groups,the expression of PCNA was high and CⅣ was low,compared with the CD44V6 negative group,it was singificant defferent between the two above groups.Conlusion CD44V6 expression may associate with tumor metastasis.

关 键 词：CD44V6 增殖细胞核抗原 Ⅳ型胶原 宫预癌 

分 类 号：R737.330.2[医药卫生—肿瘤]