TACE联合^(131)I碘化油内放射治疗原发性肝细胞癌疗效观察  

Transcatheter Arterial Chemo Embolization Combined with ^(131)I Lipiodol for the Treatment of Primary Hepatocellular Carcinoma

作　　者：胡伟民 王俊 付文海 任志刚 阮钟鸣 刘海鹰 

机构地区：[1]广州市肿瘤医院,510095

出　　处：《实用癌症杂志》2000年第4期410-412,共3页The Practical Journal of Cancer

基　　金：广州市科委重点科研项目!资助 (No .96 z 70 9)

摘　　要：目的　探讨原发性肝细胞癌肝动脉栓塞化疗 (TACE)联合13 1I 碘化油内放射治疗的疗效。方法　原发性肝细胞癌 68例 ,随机分为 2组进行治疗。A组 (TACE组 ) :经导管肝动脉栓塞化疗 ,3 4例 ;B组 (联合治疗组 ) :肝动脉栓塞化疗联合13 1I 碘化油内放射治疗 ,3 4例。结果　TACE组二期手术切除率 8.8% ,组织学检查切除病灶的完全坏死率为 0 ,患者 1、2、3年生存率分别为64 .3 %、3 9.3 %和 2 1.4%。联合治疗组二期手术切除率 2 9.4% ,切除病灶完全坏死率为 76.9% ,1、2、3年生存率分别为 96.4%、82 .1%和 60 .7%。 2组 1、2、3年生存率、二期手术切除率和肿瘤坏死率相比较 ,均有显著性差异 (P <0 .0 5 )。结论　TACE联合13 1I 碘化油内放射治疗效果优于单纯栓塞化疗。Objective To study the therapeutic effect of transcatheter arterial chemoembolization(TACE) combined with iodine 131 Lipiodol( 131 I Lipiodol) for primary hepatocellular carcinoma(PHC).Methods 68 patients with PHC were divided into two groups.In group A,34 patients were treated by TACE,and in group B,34 patients treated by TACE combined with 131 I Lipiodol.Results In group A, second stage surgical resection rate was 8.8%,histologic examination of cancer specimens obtained from hepatectomy showed that TACE could not cause complete necrosis.The 1 ,2 ,and 3 year survival rate of the treated cases was 64.3%, 39.3% and 21.4%,respectively.In contrast,in group B,the second stage surgical resection rate was 29.4%,combination therapy resulted in complete histologic necrosis in 76.9% of patients.The 1 ,2 ,and 3 year survival rate was 96.4%,82.1% and 60.7%,respectively.Conclusion The therapeutic effect of TACE combined with 131 I Lipiodol is much better than that of TACE alone.

关 键 词：肝细胞癌 内放射治疗 肝动脉栓塞化疗 TACE 碘13 

分 类 号：R735.705[医药卫生—肿瘤] R730.58[医药卫生—临床医学]