MNU诱导的大白鼠膀胱肿瘤动物模型  

Expermental Model of Bladder Tumors in Rats Induced by MNU

作　　者：刘红耀[1] 刘春[1] 米振国[1] 王东文[1] 李春华[2] 李柄太 佟锦[1] 

机构地区：[1]山西医科大学第一医院泌尿外科,太原030001 [2]山西医科大学中心实验室,太原030001 [3]山西医科大学电镜室,太原030001

出　　处：《肿瘤防治研究》2000年第4期241-243,共3页Cancer Research on Prevention and Treatment

基　　金：山西省科学基金!资助项目 (9710 2 4)

摘　　要：目的　研究N - -甲基亚硝基脲 (MNU)诱发大白鼠膀胱肿瘤的作用。方法　以MNU为诱癌剂 ,进行大白鼠膀胱灌注 ,以光镜、扫描电镜、透射电镜等为观察手段 ,对其诱发的膀胱肿瘤进行观察。结果　每次灌注MNU2mg 只 ,每 2周 1次 ,共 4次 ,8周诱发膀胱肿瘤率 10 0 % ,其组织学形态及病理特征与人膀胱肿瘤十分相似。结论　MNU诱发的大白鼠膀胱肿瘤为一理想的动物模型。Objectivc To study the experimental animal model of bladder tumors induced by MNU.Methods Bladder tumors were induced in female Wistar rats by intravesicular adminstration of the carcinogen,N-methyl -N-nitrosourea(MNU).The morphological alterations bladder epithelial cells were stuied by light micoscopy scanning and transmission electron microscopy.Results The administration way of a total dose of 8 mg on 4 fraction of 2 mg at 2- weekly intrvals produed a100%incidence of bladder toumor after 8 weeks.Histopathological characteristics of bladder tumor induced by MNU were basically similar to those of human bladder tumor.Conclusion Intravesicular administration of MNU in rats provided a useful model for experimental studies of bladder tumor.

关 键 词：化学致癌剂 MNU 甲基亚硝基脲 模型 膀胱肿瘤 

分 类 号：R73－354[医药卫生—肿瘤] R737.14[医药卫生—临床医学]