动态监测血清CA125对上皮性卵巢癌疗效及预后评估  

The Prognostic Value of the Kinetic Serum CA125 Detection in Patients with Epithelial Ovarian Cancer

作　　者：吴京[1] 林珊娜[1] 卓静[1] 

机构地区：[1]汕头大学医学院第二附属医院妇产科,广东汕头515041

出　　处：《河北医学》2012年第10期1374-1376,共3页Hebei Medicine

摘　　要：目的:探讨动态监测血清CA125在上皮性卵巢癌中的疗效评估及预测复发的临床价值。方法:采用回顾性分析方法,对2003年1月至2008年12月间在我科初治且资料完整的42例EOC患者进行血清CA125的检测,计算CA125半衰期及转阴时间,分析不同组生存期的差异及复发的情况。结果:CA125半衰期t 1/2≤20天组22例及t 1/2>20天组20例,中位生存时间分别为38月、23月,有显著性差异(P<0.05);CA125转阴时间NT≤8周组23例及NT>8周组19例,两组中位生存时间分别为37月、24月,有显著性差异(P<0.05);NT>8周组较NT≤8周组复发率高,且复发中位时间短,复发时血清CA125均大于正常值上线。结论:EOC患者术后CA125的下降速率指标(如半衰期、转阴时间)均可判断预后,但后者更简便、直观;术后CA125水平的升高可预测复发。Objective： To explore the prognostic value of the kinetic serum CA125 detection in patients with epithelial ovarian cancer.Method： The level of serum CA125 were examined in 42 patients with epithelial ovarian cancer primarily underwent operation in this hospital from Jan.2003 to Dec.2008,calculated the serum CA125 half-life and the normalized time,analyzed the median survival time and the mean time of recurrence.Result： The median survival times of patients（n=22） with CA125 half-life ≤20 days and those（n=20）20 days,were 38 months and 15 months（P0.05）.Further,patients with serum CA125 normalized time ≤8 weeks（n=23） experienced a median survival of 37 months,compared to only 23 months for those（n=19）8 weeks（P0.05）.Finally,the recurrent rate in patients with normalized time 8 weeks was higher than those ≤8 weeks.In contrast,the recurrent mean time was shorter than those ≤8 weeks.Conclusion： It is useful to predict treatment response and prognosis of epithelial ovarian cancer by serum CA125 decreased markers such as half-life and normalized time,the latter is more convenient.The increase of CA125 after treatment indicated recurrence.

关 键 词：血清CA125 半衰期 转阴时间 上皮性卵巢癌 预后 

分 类 号：R737.31[医药卫生—肿瘤]