血微量元素与儿童孤独症及症状严重程度的相关性  

The relationship between symptom severity and blood levels of serum microelements among children with autistic disorders

作　　者：李刚[1] 古田 周云 

机构地区：[1]桂林医学院附属医院医务部,541001 [2]桂林市社会福利医院

出　　处：《临床精神医学杂志》2012年第4期249-251,共3页Journal of Clinical Psychiatry

摘　　要：目的:探讨儿童孤独症患者全血微量元素含量,以及与儿童孤独症症状严重程度的相关性。方法:选取25例儿童孤独症患者作为病例组,30例健康者作为对照组,采用原子吸收分光光度法对被试的全血铜、锌、钙、镁和铁离子水平进行测定;采用儿童孤独症行为量表(AutismBehaviorChecklist,ABC)对病例组的症状进行评估。结果:与对照组相比,病例组的血镁和锌离子含量降低(t=-12.435,P<0.001;t=-11.44,P<0.001),而血铜离子含量增高(t=3.915,P<0.05),差异具有统计学意义。两组的其余血微量元素含量差异不显著。儿童孤独症行为量表的得分与血镁、锌离子含量呈显著负相关(r=-0.813,P<0.001;r=-0.785,P<0.001),与血铜离子含量呈显著正相关(r=0.466,P<0.001)。结论:孤独症患儿症状的严重水平与血镁和锌离子含量降低,血铜离子含量增高有密切关系,血微量元素含量异常可能是诊断儿童孤独症的敏感生物学指标之一。Objective ：To explore the blood levels of microelements among child with autistic disorder and its relations with symptoms severity. Method： Serum microelements were determined with atom absorbent spectrophotometry in 25 cases of autism children and 30 healthy controls. Results：Blood level of magnesium and zinc were significantly decreased in autism group compared to control group （t = -12. 435 ,P 〈0. 001 ;t = -11.44, P 〈 0. 001, respectively）. Blood level of copper was significantly increased in autism group compared to control group（ t = 3. 915, P 〈 0.05 ）. Furthermore, scores of autism behavior checklist negatively correlated with blood level of magnesium and zinc （ r = - 0. 813, P 〈 0. 001 ; r = - 0. 785, P 〈 0. 001, respectively） and positively correlated with blood level of copper （ r = 0. 466, P 〈 0. 001 ） . Conclusion ： Blood level of microele- ments is closely correlated with symptom severity of autism disorder and may be the effective biological parame- ters in the diagnosis of autism disorder.

关 键 词：儿童孤独症 微量元素 儿童孤独症行为量表 儿童期孤独症评定量表 

分 类 号：R749.94[医药卫生—神经病学与精神病学]