人乳头瘤病毒感染与宫颈癌的关系及其疫苗的研究进展  

Research Progress of Relationship Between Human Papillomavirus Vaccine and Cervical Carcinoma

作　　者：严虹月[1] 曹佩霞 

机构地区：[1]南京中医药大学第一临床医学院,江苏南京210046 [2]常州市中医院

出　　处：《中华妇幼临床医学杂志（电子版）》2012年第4期434-436,共3页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

摘　　要：人乳头瘤病毒(HPV)的持续感染已被证实是诱发宫颈癌的主要原因,其中高危型HPV(HR-HPV)-16,-18感染可引起70%以上感染者发生宫颈癌和癌前病变。因此,预防HPV感染是防治宫颈癌的主要途径。而HPV疫苗的成功研制,在预防宫颈癌方面取得巨大突破。目前,全球广泛应用的2种HPV疫苗。It is well accepted today that almost cases of carcinoma of the cervix are caused by persistent infections with human papilloma viruses （HPV）, especially high risk HPV（HR HPV）-16, -18 which accounting ：for more than 70%. The prevention of HPV infection in the development and progression o{ cervical carcinoma is very important. The success of HPV vaccine development has made great breakthrough in the prevention of cervical carcinoma. At present, two kinds of HPV vaccine were widely used in the world. They are Gardasil （antFHPV-6, -11, -16, 18, Merck ＆ Co. , Inc. , USA） and CervarixTM（anti-HPV-16, -18, GlaxoSmithKline, England）. This paper focused on the carcinogenesis and epidemiological situation of HPV, the mechanism and safety of preventive HPV vaccine.

关 键 词：人乳头瘤病毒感染 预防性疫苗 

分 类 号：R737.33[医药卫生—肿瘤]