非小细胞肺癌β防御素-1表达与树突状细胞浸润的关系  

Expression of human beta-defensin-1 and infiltration of dendritic cells in non-small cell lung cancer

作　　者：陈美芳 吕冬青 冯加喜 周建英[2] 

机构地区：[1]台州医院呼吸内科,317000 [2]浙江大学医学院附属第一医院呼吸科

出　　处：《浙江医学》2012年第14期1180-1183,1223,共5页Zhejiang Medical Journal

摘　　要：目的探讨β防御素-1（Humanbeta-defensin-1，HBD-1）表达和树突状细胞（Dendriticcells，DC）浸润与非小细胞肺癌免疫的关系。方法采用免疫组化方法检测、分析非小细胞肺癌组织和癌旁正常肺组织HBD-1的表达变化，并进一步分析其变化与未成熟树突状细胞（Immaluritydendriticcells，iDCs）浸润之间的关系。结果非小细胞肺癌组织HBD-1蛋白表达显著高于正常肺组织。且在腺癌组织表达程度高于鳞状细胞癌组织。其表达与临床分期无关。同时肺癌内存在显著的iDCs浸润。HBD-1表达水平与之呈正相关。结论在非小细胞肺癌组织内存在高水平的HBD-1蛋白表达，其表达程度与癌组织DC的浸润有关．提示HBD-1可能通过趋化未成熟的DC而在机体抗肿瘤免疫中发挥作用。Objective To investigate the expression of human beta-defensin-1 （hBD-1） and infiltration of dendritic cells （DC） in non-small cell lung cancer （NSCLC）. Methods The expression of hBD-1 in lung cancer tissues and normal tissues was detected by immunohistochemistry （EnVision）; and its correlation with DC infiltration was analyzed. Results The expression of hBD-1 in NSCLC tissue was significantly increased compared to that in normal lung tissues, and the expression level in adeno- carcinoma was higher than that in squamous cell carcinoma. The expression of hBD-1 was significantly correlated with DC infil- tration in lung cancer tissue, but not with the clinical stages of patients. Conclusion The results suggest that the up-regulated hBD-1 expression in non-small cell lung cancer may be involved in anti-tumor immunity through aggregating immature DCs in tumor tissues.

关 键 词：非小细胞肺癌 β防御素-1 树突细胞 浸润 

分 类 号：R734.2[医药卫生—肿瘤]