乳腺癌组织MT1-MMP表达与淋巴管生成的关系  

Relationship between MT1-MMP and Lymphangiogenesis in breast cancer

作　　者：姚广裕[1] 何萍[2] 杨名添[3] 刘民锋[1] 叶长生[1] 

机构地区：[1]南方医科大学南方医院乳腺中心,广州510515 [2]广州医学院第一附属医院病理科,广州510120 [3]中山大学附属肿瘤医院乳腺科,广州510515

出　　处：《重庆医学》2012年第24期2459-2461,F0002,共4页Chongqing medicine

基　　金：国家"十五"科技攻关计划资助项目(2001BA703B04)

摘　　要：目的通过分析乳腺癌组织中膜型基质金属蛋白酶-1(MT1-MMP)表达与血管内皮生长因子C(VEGF-C)、微淋巴管密度(LMVD)的关系,提供MT1-MMP参与乳腺癌淋巴管生成的证据。方法采用免疫组织化学方法检测87例乳腺癌组织中MT1-MMP、VEGF-C和D2-40的表达,分析MT1-MMP与VEGF-C、LMVD的关系及其与腋窝淋巴结转移的相关性。结果 MT1-MMP、VEGF-C的阳性表达以及肿瘤的淋巴管的高密度与腋窝淋巴结转移的增加相关。MT1-MMP阳性的患者中VEGF-C的阳性率明显高于MT1-MMP阴性的患者(86.0%vs 43.2%,P=0.000)。MT1-MMP阳性的患者中LMVD的平均值明显高于MT1-MMP阴性的患者(30.2个vs 25.1个,P=0.000)。结论 MT1-MMP与乳腺癌淋巴管生成和淋巴结转移关系密切,是参与乳腺癌淋巴管生成的重要因子。Objective To investigate evidence of MT1-MMP involved in breast cancer lymphangiogenesis process,we study the correlation between expressions of MT1-MMP and VEGF-C,LMVD in breast cancer.Methods The expressions of MT1-MMP,VEGF-C and D2-40 in 87 patients with breast cancer were detected by immunohistochenical method,and the relationship between MT1-MMP,VEGF-C,LMVD and axillary lymph node metastasis were analyzed.Results MT1-MMP,VEGF-C positive expression and high LMVD were associated axillary lymph node metastasis.The positivity rate of VEGF-C was significantly higher in MT1-MMP positive patients than that in MT1-MMP negative ones（86.0% vs 43.2%,P〈0.01）.The LMVD was significantly higher in MT1-MMP positive patients than that in MT1-MMP negative ones（30.2 vs 25.1,P〈0.01）.Conclusion The expressions of MT1-MMP is closely related to lymphangiogenesis and lymph node metastasis in breast cancer,and may be an important factor involved in breast cancer lymphangiogenesis.

关 键 词：膜型基质金属蛋白酶-1 血管内皮生长因子C 微淋巴管密度 乳腺肿瘤 

分 类 号：R737.9[医药卫生—肿瘤]