神经性厌食患者5-羟色胺2A受体基因多态性与人格特性的关联研究  

An study on the association between 5-HT2A receptor gene polymorphism and personality traits in patients with anorexia nervosa

作　　者：陈珏[1] 禹顺英[1] 贾秀珍 张燃 袁爱花 钱伊萍 虞一萍[1] 王振[1] 蒋文晖 肖泽萍[1] 张明岛[1] 

机构地区：[1]上海交通大学医学院附属精神卫生中心,上海200030

出　　处：《中国神经精神疾病杂志》2012年第8期459-463,共5页Chinese Journal of Nervous and Mental Diseases

基　　金：上海市卫生局科研基金(编号:2008097);上海交通大学医学院科技基金项目(编号:YZ1051);国家临床重点专科-上海市精神卫生中心(编号:卫生部医政司2011-873)

摘　　要：目的探讨5-羟色胺2A(5-HT2A)受体基因102T/C多态性与神经性厌食患者人格特性之间的关系。方法应用多重碱基延伸SNP分型技术,对107例神经性厌食患者进行5-HT2A102T/C基因多态进行检测,并进行明尼苏达多项人格调查表(Minnesoda Multiphasic Personality Inventory,MMPI)评定。结果 5-HT2A102T/C的三种多态基因型的Pd(心理病理性偏离)量表T分差异有统计学意义(F=7.698,P=0.001);其中,纯合子C/C和T/T基因型Pd量表T分(67.3±12.7;65.8±12.7)均高于中国常模(60),并均显著高于杂合子T/C基因型的Pd量表T分(58.2±9.8)(P1=0.001;P2=0.005)。结论 5-HT2A102T/C基因多态可能与神经性厌食的易感人格特性存在关联,MMPI中Pd量表T分很可能是神经性厌食的人格特性内表型。Objective To explore the relationship between 5-HT2A 102T/C polymorphism and personality traits in patients with anorexia nervosa. Methods The Multiplex SNaPshot SNP genotyping technique was used to an- alyze the genotypes of 5-HT2A 102T/C polymorphism and Minnesoda Muhiphasic Personality Inventory （MMPI） was applied to measure the personality traits in 107 Chinese Han patients with anorexia nervosa. Results There were sig- nificant differences in the Pd （Psychopathic Deviate） T scores among the three genotype subgroups, i.e. C/C, T/T and T/C subgroup, of 5-HTzA 102T/C polymorphism （F = 7.698, P = 0.001）. The Pd T scores was significantly higher in the homozygote genotype of both C/C and T/T （67.3 ±12.7; 65.8±12.7）than in either normal controls or in heterozygote genotype of T/C （58.2 ±9.8） （P = 0.001 and P = 0.005, respectively）. Conclusions 5-HT2A 102T/C polymorphism is probably related with the susceptive personality traits of anorexia nervosa. The Pd T score of MMPI is the probable personality endophenotype in anorexia nervosa.

关 键 词：神经性厌食 5-羟色胺 2A受体 基因多态性 人格特性 内表型 

分 类 号：R749.7[医药卫生—神经病学与精神病学]