快速老化小鼠SAMP10的老化特征及其研究进展  

Aging characteristics and progress in studies on senescence accelerated mouse prone 10(SAMP10)

作　　者：高琳娜[1] 毕明刚[2] 

机构地区：[1]河北北方学院药理学教研室,河北张家口075000 [2]中国医学科学院药用植物研究所,北京100193

出　　处：《中国药理学通报》2012年第9期1196-1199,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 30772750)

摘　　要：快速老化小鼠(senescence-accelerated mouse,SAM)是日本京都大学Takeda教授从AKR/J系小白鼠中通过表型选择培育出的快速老化模型。根据老化速度和病状特征,SAM鼠可以分为快速衰老的P系和抗快速老化的R系。快速老化小鼠SAMP10作为P系的一种,主要特征表现为与衰老相关的学习记忆障碍,具有β-淀粉样蛋白沉积、脑萎缩、神经DNA损伤、星形胶质细胞及小胶质细胞增生等病理变化,在行为学、神经递质以及分子水平方面均表现出一定的衰老变化,是目前较理想的研究阿尔采末病(AD)的动物模型。同龄对照组SAMR1具有正常的衰老特征,常用于SAMP10的正常对照。目前SAMP10是比较理想的用于研究学习记忆障碍的发病机制、评价抗衰老药物以及抗抑郁药的动物模型。The senescence-accelerated mouse have been successfully developed by selective inbreeding of the AKR/J strain of mice donated by Professor Takeda coming from Kyoto University in Japan. By aging characteristics, the SAM strains may divide into senescence-prone inbred strains （SAMP） and senescence- resistant inbred strains （SAMR）. As a strain of SAMP strains, the characteristics of senescence-accelerated mouse prone 10 （SAMP10） is aging-related impairment of learning and memory defects. The characteristics of senescence-accelerated mouse prone 10（SAMP10） is considered an effective model for studying Alzheimer＇ s disease （AD） , which has some pathological characteristics such as beta-amyloid deposition, brain atrophy,nerve DNA damage, astrocytes and microglial cell proliferation, and it has shown certain aging changes in behavior, neurotrans- mitter and molecular levels. The SAMR1 strain is usually used a normal control model which exhibits normal aging characteris- tics. The SAMP10 can be used as an animal model for the study of revealing mechanism of accelerated deficits in learning and memory, and evaluating of anti-aging drugs and antidepressant drugs.

关 键 词：快速老化小鼠SAMP10 阿尔采末病 动物模型 病 理变化 衰老变化 学习记忆 

分 类 号：R-05[医药卫生] R322.81