奥美拉唑或法莫替丁联合伊托必利治疗反流性食管炎的疗效分析  

The effect analysis of omeprazole or famotidine combined with itopride in the treatment of reflux esophagitis

作　　者：朱玉婷[1] 张曙[1] 

机构地区：[1]上海市第六人民医院金山分院消化内科,上海市201599

出　　处：《中国基层医药》2012年第17期2569-2570,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察奥美拉唑或法莫替丁联合伊托必利治疗反流性食管炎的临床疗效。方法将86例反流食管炎患者随机分为两组，A组43例采用奥美拉唑联合伊托必利治疗，B组43例采用法莫替丁联合伊托必利治疗。观察两组的临床疗效和症状评分变化。结果A组总有效率为91．3％，明显高于B组的71．7％（X2=5．460，P〈0．05）。治疗后两组反酸、烧心和胸骨后疼痛评分均明显下降（均P〈0．05），且治疗后A组反酸、烧心和胸骨后疼痛评分均低于B组（均P〈0．05）。结论奥美拉唑联合伊托必利治疗反流性食管炎优于法莫替丁联合伊托必利。Objective To observe the effect of omeprazole or famotidine combined with itopride in the treat- ment of reflux esophagitis. Methods 86 patients with reflux esophagitis were randomly divided into two groups,which group A with 43 cases was treated with omeprazole combined with itopride, and group B with 43 cases was treated with famotidine combined with itopride. The clinical effect and main symptoms were observed and compared. Results The total effective rate in group A was 91.3%, significantly higher than that of group B （71.4%） （X2 = 5. 460, P 〈 0. 05 ）. After treatment, the scores of heartburn, acid reflux and chest pain were significantly decreased （ all P 〈 0. 05 ） in both two groups. Moreover, the scores of heartburn, acid reflux and chest pain in group A after treatment were signif- icantly lower than those of group B （ all P 〈 0.05 ）. Conclusion Omeprazole combined with itopride in the treatment of reflux esophagitis is better than famotidine combined with itopride.

关 键 词：反流性食管炎 奥美拉唑 法莫替丁 伊托必利 

分 类 号：R571[医药卫生—消化系统]