人乳头瘤病毒次要衣壳蛋白L2核定位  

Nucleic localization of human papillomavirus minor capsid protein L2

作　　者：陈卫东[1] 井申荣[1] 

机构地区：[1]昆明理工大学生命科学与技术学院,昆明650500

出　　处：《生命的化学》2012年第4期364-366,共3页Chemistry of Life

基　　金：云南省应用基础研究项目(2007C032M);国家自然科学基金项目(30872398);863计划重大项目(2006AA02A227)资助

摘　　要：在人乳头瘤病毒(human papillomavirus,HPV)次要衣壳蛋白L2的N端和C端,有大量带正电荷的氨基酸残基组成核定位信号(nuclear localization signal,NLS)。细胞的核结构域10(nuclear domain 10,ND10)是细胞周期和病毒生活周期的重要调节者。L2定位到ND10的过程不仅会受到早幼粒细胞白血病蛋白(promyleocytic leukaemia protein,PML)、死亡结构域相关蛋白(deathdomain-associated protein,Daxx)、Sp100核抗原(Sp100 nuclear antigen)等细胞蛋白的影响,也会与L1在ND10发生相互作用。在HPV感染和组装过程中,L2的核定位信号有着重要作用。The nuclear localization signal, NLS, which is composed of many amino acids with positive charge residue, is located in both ends of N terminus and C terminus of the human papillomavirus minor capsid protein L2. The nuclear domain 10, ND-10, which is in the cell nucleus, is an important modulator of both cell cycle and virus cyclogeny. The process of the locating of L2 to ND-10, is not only impacted by the cell proteins, such as the promyelocytic leukemia protein, death domain-associated protein Daxx, nuclear antigen Sp 100, but also interacts with L1 in ND-10. The NLS of L2 plays a significant role during the HPV virus assembly course.

关 键 词：HPV L2 核定位 

分 类 号：R737.33[医药卫生—肿瘤]