nm23基因产物、型胶原表达与喉癌颈淋巴结转移关系的探讨  

The Relationship Between the Expression of nm23/NDPK, Type Ⅳ Collagen and the Metastasis of Cervical Lymph Node in Laryngeal Squamous Cell Carcinoma

作　　者：蔡群峰[1] 任重[1] 关超[1] 

机构地区：[1]中国医科大学第一临床学院耳鼻喉科,沈阳110001

出　　处：《中国医科大学学报》2000年第4期294-296,共3页Journal of China Medical University

摘　　要：目的 :研究转移抑制基因 nm 2 3表达产物二磷酸核苷激酶 (NDPK)和基底膜主要成分 型胶原在喉癌中的表达与颈淋巴结转移之间的关系。方法 :应用 S- P免疫组织化学方法检测 6 9例声门上型喉癌 nm 2 3/ NDPK、 型胶原的表达。结果 :喉癌 nm 2 3/ NDPK阳性表达率、 型胶原完整表达率分别为 6 2 .2 % (4 5 / 6 9)、39.1% (2 7/ 6 9) ,在颈淋巴结转移组中分别为 36 .4% (12 / 33)、2 1.2 % (7/ 33) ,在无颈淋巴结转移组中分别为 91.7% (32 / 36 )、5 5 .6 % (2 0 / 36 ) ,差异有显著性。 nm 2 3/ NDPK不表达、 型胶原不完整与颈淋巴结转移相关 ,具有一致性。结论 :nm 2 3/ NDPK、 型胶原表达与喉癌颈淋巴结转移呈负相关 ;nm 2 3、 型胶原在限制喉癌颈淋巴结转移过程中具有一致性。Objective:Our aims were to study the expression of nucleoside diphosphate kinase(NDPK),type Ⅳ collagen in laryngeal squamous cell carcinoma and to investigate the relation between NDPK,type Ⅳ collagen and cervical lymph node metastasis.Methods:Streptavidin peroxidase conjugated method was used to detect the expression of NDPK and type Ⅳ collagen in 69 patients.Results:In laryngeal carcinoma patients,the rate of the positive expression of nm23/NDPK and type Ⅳ collagen continuity were 62.2 %(45/69)and 39.1%(27/69) respectively. In patients with cervical lymph node metastasis the rate were 36.4 %(12/33) and 21.2%(7/33) respectively. In patients without cervical lymph node metastasis the rate were 91.7 %(32/36) and 55.6%(20/36) respectively.Non-nm23 expression and type Ⅳ collagen discontinuity were related with cervical lymph node metastasis.Conclusion:Expression of nm23 and type Ⅳ collagen were negatively related with cervical lymph node metastasis,they play the same role in restricting cervical lymph node metastasis in patients with laryngeal squamous cell carcinoma.

关 键 词：喉肿瘤 NM23基因 Ⅳ型胶原 颈淋巴结转移瘤 

分 类 号：R739.65[医药卫生—肿瘤] R733.4[医药卫生—临床医学]