基因芯片技术在牙髓生物学研究中的应用进展  

Research progress on gene chip technology and its applications in dental pulp biology

作　　者：龚启梅[1,2] 凌均棨[1,2] 

机构地区：[1]中山大学光华口腔医学院.附属口腔医院牙体牙髓病科 [2]广东省口腔医学重点实验室,广州510055

出　　处：《国际口腔医学杂志》2012年第5期608-611,616,共5页International Journal of Stomatology

摘　　要：基因芯片作为一种高通量、快速和平行核酸序列测定及定量分析技术已经广泛地应用于分子生物学领域。牙髓基因组学的研究将有利于加强人们对牙髓生理和病理机制的认识,从而最终应用于临床预防、诊断和治疗等,因此,本文就基因芯片技术及其与牙髓干细胞相关的基因、牙髓老龄化改变相关的基因和龋病时牙髓相关的基因等研究进展作一综述。Gene chip was a high-throughput, rapid, parallel nucleic acid sequence detection and quantitative analysis technology. It has been widely used in molecular biology in recent years. Study on dental pulp genomics will help to understand the physiological and pathological mechanisms of pulp, thus contributing to the clinical application in prevention, diagnosis and treatment. In this review, we briefly described the gene chip technology and its applications in dental pulp stem cells, aged dental pulp and dental caries.

关 键 词：牙髓 牙髓细胞 基因芯片 基因表达谱 

分 类 号：R780.2[医药卫生—口腔医学]