口腔癌患者情绪异常与下丘脑-垂体-肾上腺轴的调节障碍  

Relationship between the mood disorders of patients with oral cancers and disruptions in hypothalamic-pituitary-adrenal axis

作　　者：经典 贾燕飞[2] 刘传霞[3] 周奇志[2] 

机构地区：[1]四川大学华西口腔医学院,成都610041 [2]国家中医药管理局时间生物学实验室,成都中医药大学,成都610075 [3]四川大学华西口腔医院黏膜科,成都610041

出　　处：《国际口腔医学杂志》2012年第5期628-630,共3页International Journal of Stomatology

基　　金：国家自然科学基金资助项目(81173322);四川省科技厅基金资助项目(2010JY0036)

摘　　要：口腔癌是头颈部最常见的肿瘤,患者多伴有焦虑或抑郁情绪,而情绪异常又是癌症发生发展的"催化剂"和预后的预报器。口腔癌的情绪异常与下丘脑-垂体-肾上腺(HPA)轴调节紊乱应有一定关联性。本文提示以神经内分泌重要环节——HPA轴调节紊乱为重要切入点,探讨口腔癌情绪异常的生物学机制,可为口腔癌的情绪异常及其干预措施的机制研究提供新思路,具有重要意义。Oral cancer is the most common neoplasm of the head and neck. Patients with oral cancer show elevated prevalence rates of mood disorder. Mood disorder is a kind of ＇catalyst＇ in the development of cancer and the prognosis predictor. Mood disorder in oral cancer may be associated with circadian disruption in hypothalamic-pituitary-adrenal （HPA） axis. Based on this analysis, we recommend that alteration of circadian rhythm of the HPA axis may play a crucial role in biology mechanism of intervention on oral cancer with mood disorder.

关 键 词：口腔癌 情绪障碍 下丘脑-垂体-肾上腺轴 

分 类 号：R739.8[医药卫生—肿瘤]