检查Cox模型比例风险假定的几种图示法  

Graphical Methods for Investigating the Proportional Hazards Assumption in Cox Model

作　　者：余红梅[1] 何大卫[1] 

机构地区：[1]山西医科大学卫生统计学教研室,030001

出　　处：《中国卫生统计》2000年第4期215-218,共4页Chinese Journal of Health Statistics

基　　金：全国统计科学研究项目;山西省归国人员基金项目

摘　　要：目的　检查Cox模型比例风险假定图示法的应用与比较。方法　介绍了基于Cox模型与kaplan -meier法生存估计比较、Cox模型累积风险函数、schoenfeld残差和score残差的图示法。结果　上述几种图示法均可不同程度地检查PH假定。结论　建议使用schoenfeld残差图和score残差图 ,除评价PH假定外 ,前者可提供LHRF的非参数估计 。Objective To apply and compare graphical methods for dedecting vialations of the proportional hazards assumption in Cox model.Methods We introduce methods of comparing survival estimates based on Cox model with kaplan-Meier estimates,cumulative hazard functions,schoenfeld residuals and score residuals.Results the above graphical methods can to assess PH assumption a certain extent.Conclusion plots of schoenfeld residuals and score residuals are recommended because the former can provide non-parametric estimates of the LHRF;the latter is useful for investigating the leverage of each subject upon the estimates of β.

关 键 词：COX模型 比例风险 拟合优度 残差 图示法 

分 类 号：R195[医药卫生—卫生统计学]