婴儿颅内出血与髓鞘碱性蛋白的关系  

Relation between intracranial hemorrhage of infant and myelin basic protein

作　　者：杨思达[1] 何馨[1] 杨镒宇[1] 祝惠华[1] 何旦莎[2] 邓维意[2] 

机构地区：[1]广州市儿童医院神经科,510120 [2]广州医学院神经科学研究所,510180

出　　处：《广州医药》2000年第4期7-8,共2页Guangzhou Medical Journal

摘　　要：目的：检测颅内出血患儿脑脊液和血清髓鞘碱性蛋白（ＭＢＰ）的含量，探讨本病脑损害和ＭＢＰ含量变化的关系。方法：采用简易 ＭＢＰ ＥＬＩＳＡ法对３８例脑实质（或伴腔室）出血及腔室内（硬膜下腔、蛛网膜下腔、脑室）出血患儿脑脊液和血清标本作 ＭＢＰ定量测定，与对照组比较，并于治疗 ４－５周后复查对比。结果：两出血组脑脊液和血清 ＭＢＰ的含量明显高于对照组（Ｐ均＜０．０１），有脑实质出血组脑脊液和血清 ＭＢＰ含量亦高于腔室内出血组（Ｐ＜０．０１），治疗后ＭＢ Ｐ含量未见下降。结论：脑脊液和血清ＭＢＰ定量测定作为生化方面的指标丰富了本病诊断的实验室检查内容，有助于本病的预后评估。Objective: To investigate the quantitative of myelin basic protein (MBP) in cerebropinal fluid (CSF) and serum in intracranial hemorrhage (ICH) infant, study the relation between ICH and quan- titative MBP. Methods: 38 cases were studied with easy MBP - ELESA method; 16 cases of study group I were substantial (or combined with ventricular) hemorrhage, while 22 of study group II were non - substantial one. There were 10 cases in control group their quantitative MBP in CSF and serum were comparatively tested, then were repeated and compared among them after treatment for 4-5 weeks. Results: Quantitative values MBP in CSF and serum in both of study groups were significantly higher than control group (P <0.01), while values in substantial group were also distinctive1y higher than non - substantial one (P <0.01) . There was no decreased values of MBP after treatment for 4-5 weeks. Conclusion: The quantita tive test for MBP in CSF and serum can be used as a biochemical guideline which dose enrich the lab examinations for the diagnosis to this disease, and is a helpful prediction for its prognosis.

关 键 词：婴儿 颅内出血 髓鞘碱性蛋白 维生素K缺乏 

分 类 号：R743.34[医药卫生—神经病学与精神病学]