瘦素、脂蛋白α在食管鳞状细胞癌中的表达及其临床意义  

Expressions of leptin and lipoprotein α in esophageal squamous cell carcinoma and their clinical significance

作　　者：张双平[1] 汪善兵[2] 陈芸[1] 王春利[1] 贾钰铭[2] 张霞[2] 

机构地区：[1]山西省肿瘤医院胸外二科,太原030013 [2]四川省宜宾市第二人民医院肿瘤科

出　　处：《肿瘤研究与临床》2012年第7期440-443,共4页Cancer Research and Clinic

摘　　要：目的探讨食管鳞状细胞癌（食管鳞癌）患者血清瘦素、血脂水平以及临床意义，为食管鳞癌的防治提供科学依据。方法收集术前未经任何治疗的食管鳞癌患者47例，健康对照组20名，采用酶联免疫吸附法（ELISA）测定血清瘦素水平，全自动生化分析α测定血脂水平，采用SPSS17．0软件对数据进行t检验、相关性分析、Logistic分析等统计学处理。结果食管鳞癌患者及健康对照血清瘦素水平分别为（13．09±5．94）ng／ml、（7．58±4．16）ng／ml，差异有统计学意义（t=3．76，P=0．001）；脂质蛋白仅（LPd）水平分别为（216．50±152．53）mg／L和（87．85±10．73）mg／L，差异有统计学意义（t=3．751，P=0．001），而食管鳞癌患者三酰甘油（TG）水平[（1．23±0．46）mmol／L]明显低于对照组[（1．58±0．07）mmo]／L]，差异有统计学意义（t=-3．342，P=0．001）。Logistic回归分析结果显示，瘦素水平的增高，增加了食管鳞癌的发生风险（ORleptin=1．442，P=0．009），而TG、LPa水平的改变并不影响食管鳞癌的发生风险。结论血清瘦素水平的升高可能增加食管鳞癌的发生风险，LPα水平的升高可能是机体的一个代偿反应。Objective to investigate serum leptin concentration and lipdid levels in patients with esophageal squamous cell carcinoma and their clinical significance. Methods Blood samples were collected from 47 patients with esophageal cancer, 20 healthy control subjects. Serum leptin was measured by ELISA and serum lipids was measured by biochemistry auto-analyzer. Results The serum leptin concentration and LP αlevels in patients group were significantly higher than those in control group[（13.09±5.94） ng/ml vs （7.584± 4.15） ng/ml,（216.50±752.52） ng/ml vs（87.85±10.73） mg/L]（P=0.001）. However, the TG concentration was significantly lower than control group [（1.23±0.46） mmol/L vs （1.58±0.07） mmol/L] （P=0.001）. Multiple logistic regression analysis revealed statistically significant association between serum leptin levels and esophageal squamous cell carcinoma incident （ORleptin =1.442,95% CI 1.094-1.848）. Conclusion The increased serum leptin levels maybe the risk factors of esophageal cancer, elevated LP α levels in patients might be a compensatory reactions.

关 键 词：食管肿瘤 癌 鳞状细胞 血脂 瘦素 

分 类 号：R735.1[医药卫生—肿瘤]