抑癌基因PTEN在胃癌中的研究进展  

Research progress on tumor suppressor gene PTEN in gastric carcinoma

作　　者：巩方明(综述)[1] 刘洪俊(审校)[2] 

机构地区：[1]山东省医学科学院附属医院外二科,济南250031 [2]山东大学附属省立医院胃肠外科

出　　处：《肿瘤研究与临床》2012年第7期495-497,共3页Cancer Research and Clinic

摘　　要：PTEN是迄今发现的第一个具有双特异性磷酸酶活性的抑癌基因，其主要通过PIP3途径、FAK途径、MAPK途径等发挥其脂质磷酸酶和蛋白磷酸酶活性，诱导细胞凋亡、抑制细胞生长、调节细胞迁移与黏附。PTEN蛋白在胃癌组织中表达下降，提示PTEN基因的异常改变参与了胃黏膜细胞的恶性转化过程，PTEN蛋白表达水平可作为评价胃癌病理生物学行为的客观指标之一。PTEN is a tumor suppressor with double specific phosphatase activity,and PTEN brings into its lipid and protein phosphatase activity through PIP3 , FAK, MAPK pathway. PTEN also induces apoptosis, inhibits cell growth, and regulates cell migration and adhesiveness. PTEN expression is lower in gastric carcinoma. It may be valuable to evaluate that the abnormal expression of suppressor gene PTEN participates in the malignant conversion process of the gastric mucosa cell, and the expression levels of the PTEN protein can be used to evaluate the pathologic biology behavior of gastric carcinoma.

关 键 词：胃肿瘤 PTEN 抑癌基因 

分 类 号：R737.9[医药卫生—肿瘤]