更逍遥冲剂对更年期抑郁症模型大鼠行为学以及学习记忆能力影响的观察  

Observation of the Effect of Gengxiaoyao Granule on Perimenopausal Depression Model Rats Behavior and Learning

作　　者：禄颖[1] 苏晶[2] 余轶群[3] 郑丰杰[1] 柴新楼[1] 徐雅[1] 

机构地区：[1]北京中医药大学基础医学院,北京100029 [2]香港大学专业进修学院 [3]北京中医药大学东方医院,北京100078

出　　处：《现代生物医学进展》2012年第22期4241-4244,共4页Progress in Modern Biomedicine

基　　金：香港大学专业进修学院科研经费资助项目-更逍遥冲剂治疗更年期抑郁症的临床与实验研究

摘　　要：目的:通过对更年期抑郁症模型大鼠行为学以及学习记忆的观察,探讨中药复方更逍遥冲剂的作用机制。方法:SD雌性大鼠40只,随机分为假手术组、更年期抑郁症模型组、中药中剂量组、中药大剂量组和西药对照组,观察开野实验中大鼠活动度、强迫游泳中大鼠的不动时间、以及通道式水迷宫检测大鼠学习记忆能力。结果:模型大鼠经过21d治疗后,开野实验水平积分、垂直积分明显增加,强迫游泳不动时间缩短,水迷宫实验游出时间缩短,错误次数减少。结论:更逍遥冲剂能够明显的改善更年期抑郁症大鼠的行为学评分,并具有改善其学习记忆能力的作用。Objective：To investigate the Gengxiaoyao Granule＇s mechanism of action,through the observation of perimenopausal depression model rats behavior and learning.Methods：40 SD female rats,were randomly divided into sham operation group,model group,middle dose Chinese medicine group,high dose Chinese medicine group and Western medicine group;we observed rat activity in the open field test,the immobility time on forced swimming,and memory ability through channel type water maze.Results：Model of rat after treatment with 21d,level integration,vertical integration in the open field tests was significantly increased,immobility time of forced swimming was reduced;in channel type water maze experiment,travel time were significantly shortened,and the error time was reduced.Conclusion：Gengxiaoyao granule can obviously improve the behavior scores of perimenopausal depression rats,and has improved the ability of learning and memory.

关 键 词：更年期抑郁症 行为学 学习记忆能力 更逍遥冲剂 

分 类 号：Q953[生物学—动物学] R749[医药卫生—神经病学与精神病学]