HPV-DNA亚型检测联合液基细胞学对宫颈癌筛查的临床价值  

Types of HPV-DNA Testing Combined with Liquid-Based Cytology for Cervical Cancer Screening Clinical Value

作　　者：艾永生[1] 桂文武[2] 孟江萍[2] 幸贵邦[2] 李恬[2] 

机构地区：[1]重庆合川区人民医院妇产科,重庆401520 [2]重庆医科大学附属第一医院妇产科辅助生殖中心,重庆400016

出　　处：《现代生物医学进展》2012年第22期4284-4287,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨HPV-DNA亚型检测联合液基细胞学对宫颈癌筛查的临床价值。方法:对自愿接受宫颈癌筛查的女性1462例作为研究对象,分别对其进行HPV-DNA亚型检测以及液基细胞学的检查,对于出现阳性的患者进行病理组织学检查。结果:HPV+TCT对宫颈癌早期病变以及癌变的检出率为69.67%明显高于HPV检查的56.28%以及TCT检查的63.89%(P<0.05);HPV+TCT对CINⅠ、CINⅡ、CINⅢ、癌的检出率分别为91.67%,92.86%、91.67%以及100%。结论:采用HPV-DNA亚型检测联合液基细胞学对宫颈癌筛查,可明显提高其对癌前病变的检出率,是一种高效、简单的检测方法。Objective：To investigate the subtypes of HPV-DNA testing combined with liquid-based cytology for cervical cancer screening clinical value.Methods：voluntary acceptance of women 1462 cases of cervical cancer screening as a research object,respectively,its subtype HPV-DNA testing and liquid-based cytology examination,the patients were positive for histopathological examination.Results：HPV ＋ TCT cervical cancer early lesions and cancer detection rate was 69.67% higher than HPV examination 56.28% and TCT examination of 63.89%（P 0.05）;HPV ＋ TCT for CIN Ⅰ,CIN Ⅱ,CIN Ⅲ,cancer detection rate were 91.67%,92.86%,91.67% and 100%.Conclusion：The detection of HPV-DNA subtypes combined liquid-based cytology for cervical cancer screening,can significantly improve the detection rate of precancerous lesions,is an efficient and simple detection method.

关 键 词：人乳头瘤病毒 液基细胞学 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]