变应性疾病的遗传学研究  

Genetic study of allergic diseases

作　　者：张媛[1] 张罗[1] 

机构地区：[1]首都医科大学附属北京同仁医院耳鼻咽喉头颈外科教育部耳鼻咽喉头颈外科重点实验室(首都医科大学)北京市耳鼻咽喉科研究所

出　　处：《临床耳鼻咽喉头颈外科杂志》2012年第17期809-813,共5页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：国家杰出青年科学基金(No:81025007);国家自然科学基金(No:30973282;No:81100706和No:81100704);北京市科技计划项目(No:Z111107055311040);北京市教委科技计划重点项目No:(KZ201110025027);北京市自然基金(No:7102030);北京市卫生系统高层次卫生技术人才学科带头人(No:2009-02-007);北京市科技新星计划(No:2010B022;No:Z111107054511061);北京市卫生局;北京市中医管理局青年科学研究资助课题(No:QN2008-024)

摘　　要：本文所述的变应性疾病是指IgE介导的I型变应性疾病，主要包括哮喘、变应性鼻炎（allergic rhinitis，AR）、特应性皮炎（atopic dermatitis，AD）以及食物过敏等。目前的观点认为变应性疾病属多基因病，其遗传受遗传因子和环境因素的共同控制，同时存在基因一基因、基因一环境之间的相互作用。本文旨在对包含AR在内的变应性疾病的遗传学研究策略、研究进展、研究的内在困难以及未来临床应用前景等方面做一概述。Summary Allergic diseases mentioned in this review is regarding to I type allergic inflammation induced by an IgE-mediated reaction, including asthma, allergic rhinitis, atopie dermatitis and food allergy. It is convinced that allergic diseases belong to multiple genes diseases and are controlled by both genetic and environmental factors. Meanwhile there exists gene-gene as well as gene-environment interactions during the development of the disease. The aim of this review is to summarize the toolkit, advance, inherent difficulties and future clinical application prospect in genetic studies of allergic disease.

关 键 词：变应性疾病 鼻炎 变应性 遗传学 基因 

分 类 号：R765[医药卫生—耳鼻咽喉科]