同型半胱氨酸、超敏C-反应蛋白、脂蛋白(a)联合检测在急性脑梗死中的应用价值  

Value of joint detection of homocysteine,high sensitive C-reactive protein and lipoprotein in acute cerebral infarction

作　　者：薛邦禄[1] 李妍[1] 徐维家[1] 

机构地区：[1]辽宁省大连市中心医院检验科,辽宁大连116033

出　　处：《中国卫生检验杂志》2012年第8期1888-1889,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的:探讨急性脑梗死患者血清同型半胱氨酸(Hcy),超敏C-反应蛋白(hs-CRP)和脂蛋白(a)[LP(a)]水平的变化及临床意义。方法:检测127例急性脑梗死患者和60例健康对照组血清Hcy、hs-CRP、LP(a)含量,并进行统计学分析。结果:急性脑梗死组Hcy、hs-CRP、LP(a)水平明显高于健康对照组(P<0.01),脑梗死不同临床分型组间血清Hcy、hs-CRP、LP(a)水平两两比较差异有统计学意义(P<0.01)。结论:Hcy、hs-CRP、LP(a)作为动脉粥样硬化的独立危险因素,是急性脑梗死患者重要的血清标志物,三者联合检测对评价脑梗死的发生及判断病情具有重要的临床价值。Objective：To investigate the changes and clinical significance of serum homocysteine （HCY） and high sensitive C - reactive Protein （hsCRP） and lipoprotein （a） （ LP（a） ） in patients with acute cerebral infarction. Methods： The levels of Hcy, hsCRP, LP（a） were measured in 127 patients with acute cerebral infarction and 60 healthy controls and the results were made statistical analysis. Results： The levels of Hcy, hsCRP, LP （a） in pa- tients with acute cerebral infarction were signigicantly higher than those in healthy controls（ P 〈0.01 ）, while Hcy, hsCRP, LP （a） had statistical signigicance among different clinical subtype groups of cerebral infarction （P 〈 0.01 ）. Conclusion： Hcy, hsCRP, LP（a） are independent risk factors for atherosclerotic, important serum markers for acute cerebral infarction. Joint detection of the three markers can significantly raise the isolating rate, have clinical significance for evaluating the prediction, dignosis, prognosis of patients with cerebral infarction

关 键 词：同型半胱氨酸 超敏C-反应蛋白 脂蛋白(a) 急性脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]