高龄老人血浆超氧化物歧化酶和丙二醛与认知功能的关系  

Association of cognitive function with superoxide dismutase and malondialdehyde in the oldest old

作　　者：洪文钊[1] 殷召雪[2] 

机构地区：[1]安徽省合肥市巢湖市疾病预防控制中心,合肥238000 [2]中国疾病预防控制中心慢性病防治与社区卫生处,北京102206

出　　处：《中国卫生检验杂志》2012年第8期1940-1943,共4页Chinese Journal of Health Laboratory Technology

基　　金：国家自然科学基金(70533010);NationalInstituteonAging(GrantR01AG23267-01)

摘　　要：目的:分析高龄老人血浆超氧化物歧化酶(SOD)、丙二醛(MDA)与认知功能的关系。方法:通过问卷调查基本信息、生活方式及认知功能等,测定血浆相关生化指标及SOD和MDA水平。logistic回归分析和多元线性回归模型研究认知功能与SOD、MDA水平的关系。结果:与最低水平组比较,最高水平组SOD下认知受损发生的OR(95%CI)为3.96(1.66-9.45)。SOD水平与认知功能评分之间显著相关(P<0.05),MDA与认知功能评分之间无显著相关性(P>0.05)。结论:高龄老人中血浆SOD活性与认知功能呈负向关系,未发现血浆MDA与认知功能有显著关系。Objective：To study the association of cognitive function with superoxide dismutase （SOD） and malondialdehyde （MDA） in the oldest - old aged 90 years and over. Methods ： From 5 longevity areas, all centenarians were included, and the old aged 90 -99 were matched and recruited. Information including basic information, smoking status, drinking status and leisure activities was collected by questionnaire; cognitive function was assessed by mini - mental state examination （MMSE）. 4 ml venous blood sample was collected to determine the level of tri- glycerides, total cholesterol, high density lipoprotein cholesterol, fasting plasma glucose, SOD, MDA, uric acid, Cu and Zn. General lineal model was used to test the lineal trend of MMSE scores with the level of SOD and MDA. Logistic regression was used to analyze association of cognitive function with the level of SOD and MDA. Multivariate linear regression model was fit to study the association of MMSE scores with SOD and MDA. Results： t - test showed, comparing with cognitive normal group, SOD activity of cognitive impairment group （31.85 _＋ 5.31 U/ml） was higher significantly （P 〈 0. 0001 ）, the level of MDA was lower （P 〈 0.05 ）. MMSE scores increased with in- creasing quartile of the level of SOD （ p for linear trend 〈 0.05 ）, but not with that of MDA, after exclusion of the confounded variables. Logistic regression showed OR value of SOD in the highest quartile level was 3.96 （ 1.66 - 9.45 ）, comparing with the lowest quartile level. Multivariate linear regression also showed SOD activity was associated with MMSE scores （ P 〈 0.05 ）, while MDA not （ P 〉 0.05 ）, after the confounded factors were adjusted. Conclusion： SOD activity was inversely associated with cognitive function among the oldest - old, while MDA was not found to be associated with cognitive function.

关 键 词：氧化应激 超氧化物歧化酶 丙二醛 认知功能 高龄老人 

分 类 号：R749.16[医药卫生—神经病学与精神病学]