OVA66在胃癌中的表达及临床意义  

Expression and Clinical Significance of OVA66 in Gastric Cancer

作　　者：黄宝俊[1] 杨帆[2] 赵雨杰[3] 李腾[2] 徐惠绵[1] 

机构地区：[1]中国医科大学附属第一医院肿瘤外科,沈阳市110001 [2]中国医科大学 [3]中国医科大学生物芯片中心

出　　处：《中国肿瘤临床》2012年第16期1176-1179,共4页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金项目(编号:30672050)资助~~

摘　　要：目的:研究OVA66在胃癌中的表达情况,及其与胃癌侵袭、转移和预后的相关性。方法:以52例胃癌患者为研究对象,分别运用RT-PCR、免疫组化方法检测OVA66在胃原发癌、癌旁正常胃黏膜、淋巴结转移癌中的表达,对所有病例进行随访,分析OVA66与胃癌侵袭、转移和预后的相关性。结果:OVA66在胃原发癌和淋巴结转移癌中表达明显增高,而在癌旁正常胃黏膜中几乎不表达,差异具有显著性(P<0.05)。OVA66表达在浸润型癌、癌侵透浆膜、浆膜受侵面积>20 cm^2、淋巴结分期晚者中明显增高(P<0.01)。OVA66高表达组患者5年生存率为27.5%,而OVA66低表达组为58.3%,差异有统计学意义(χ~2=10.10,P=0.0015)。结论:OVA66基因表达与胃癌的侵袭、转移和预后有关,是反映胃癌恶性生物学行为较好的分子指标。Objective： This study investigates the expression of OVA66 in gastric cancer and evaluates the correlation between expression and invasion and between metastasis and prognosis. Methods： A total of 52 patients with gastric cancer were selected and followed up. The expression of OVA66 in the primary focus of the stomach, normal gastric mucosa, and metastatic lymph node were ex- amined by reverse transcription-polymerase chain reaction （ RT - PCR ） and immunohistochemistry, respectively. The correlations between the OVA66 expression and tumor invasion, metastasis, and prognosis, were assessed. Results： The expression of OVA66 in gastric primary focus and metastatic lymph nodes significantly increased, but was nearly absent in the normal gastric mucosa （ P 〈 0.05 ）. The expression of OVA66 was significantly higher in patients with infiltrating-type gastric cancer, penetrated serosa, areas of serosa over 20 cm2, and metastatic nodes over 7 （ P 〈 0.01 ）. The patients with a higher OVA66 expression （ 27.5 % ） had a significantly lower survival rate compared with that of patients with lower OVA66 expression （ 58.3 % ）, X2 = 10.10, P = 0.001 5 ）. Conclusion： The up-regulated expression of OVA66 has a major fimction in tumor invasion, metastasis, and poor prognosis. The expression of OVA66 is a good molecular marker that reflects the biological behaviors of gastric cancer.

关 键 词：胃癌 OVA66 侵袭 转移 预后 

分 类 号：R735.2[医药卫生—肿瘤]