银屑病与早幼粒细胞白血病基因的关系  

Relationship between promyelocytic leukemia genes and psoriasis

作　　者：李娜[1] 何焱玲[1] 

机构地区：[1]首都医科大学附属北京朝阳医院,北京100020

出　　处：《国际皮肤性病学杂志》2012年第5期326-328,共3页International Journal of Dermatology and Venereology

基　　金：北京市自然科学基金（7102060）

摘　　要：银屑病是一种慢性炎症性疾病，其具体发病机制至今尚未阐明。既往研究发现，银屑病患者基因组存在自身不稳定性，而临床中发现部分银屑病患者在疾病的发生发展过程中出现了骨髓造血干细胞的损伤，表现为体细胞染色体的突变而发生白血病，尤其以急性早幼粒细胞白血病为主。早幼粒细胞白血病基因是导致早幼粒细胞白血病发病的主要原因，而早幼粒细胞白血病基因在维护银屑病基因组稳定性中具有重要作用，二者之间的关系有待进一步研究。Psoriasis is a chronic inflammatory disease of unknown pathogenesis. Previous studies revealed that the genome of patients with psoriasis is instable. Damage in bone marrow hematopoietic stem cells has been reported to occur during the occurrence and development of psoriasis, which is manifested as the mutation of somatic cell chromosome followed by the development of leukemia, especially acute promyelocytic leukemia. Promyelocytic leukemia genes are primarily responsible for the development of promyelocytic leukemia, and also play an important role in maintaining genomic stability in patients with psoriasis. Further research is required to define the roles of promyelocytic leukemia genes.

关 键 词：银屑病 白血病 早幼粒细胞 急性 基因 

分 类 号：R733.71[医药卫生—肿瘤]