突变型P53蛋白在皮肤黑素瘤中的检测及临床意义  

Level and Clincal Significance of Mutant Type P53 in Cutaneous Malignant Melanoma

作　　者：吴斌[1] 彭春[2] 

机构地区：[1]三峡大学仁和医院皮肤科,湖北宜昌44300 [2]河南焦作市人民医院病理科,河南焦作454000

出　　处：《中国皮肤性病学杂志》2012年第9期779-781,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的探讨突变型P53蛋白在黑素瘤组织中的检测及临床意义。方法SP免疫组化法检测突变型P53蛋白在40例原发性皮肤黑素瘤中的水平,以20例色素痣作为对照。结果突变型P53蛋白在皮肤黑素瘤和色素痣中的阳性率分别为80.00%和20.00%,其在黑素瘤中的水平明显高于色素痣中,两组相比差异有统计学意义(P<0.05)。突变型P53蛋白分布与黑素瘤病理学类型、病理分级、分期、淋巴结转移及预后相关。结论突变型P53蛋白在皮肤黑素瘤中的较高水平,对皮肤黑素瘤的辅助诊断及预后评估具有重要的临床意义。Objective To investigate the mutant of P53 and its clinical significance in cutaneous malignant melanoma （CMM）. Methods The expression of P53 protein was detected by Streptavidin-Peroxidase complex immunnhistochemical technique in 40 cases of CMM and 20 cases of nevus. Results The positive level of mutant type P53 in CMM was 80.00% while it was 20.00% in control group. The expression levels of mutant type P53 in CMM were significantly higer than that in nevus. The expression levels of mutant type P55 in CMM was positively related to pathological histology, Clark＇ S grade, the metastasis to lymph nodes and clinical outcome. Conclusion The expression levels of mutant type P53 shows high degree in CMM and have important implications in the diagnosis and prognostic assessment.

关 键 词：P53蛋白 黑素瘤 皮肤 

分 类 号：R739.5[医药卫生—肿瘤]