GST-π、P-gp和Ts在消化道肿瘤中的表达及临床意义  

The expresssion and significance of GST-π,P-gp and Ts in gastrointestinal carcinomas

作　　者：叶正龙[1] 盛德平[1] 杨勇[2] 王玮[3] 李卫星[1] 叶国祥[1] 周文燕[1] 

机构地区：[1]扬州大学医学院附属扬州友好医院肿瘤科,江苏扬州225009 [2]扬州大学医学院附属扬州友好医院病理科,江苏扬州225009 [3]安徽医科大学公共卫生学院流行病学与卫生统计学系,安徽合肥230032

出　　处：《现代肿瘤医学》2012年第9期1894-1896,共3页Journal of Modern Oncology

摘　　要：目的:探讨GST-π、P-gp及Ts在消化道肿瘤中的表达及其与临床病理特征的关系。方法:应用免疫组化法检测127例消化道肿瘤(32例食管癌、53例胃癌、42例结直肠癌)组织中GST-π、P-gp及Ts的表达情况,与临床病理相关资料进行回顾性分析。结果:GST-π表达阳性率80.95%、P-gp表达阳性率44.86%及Ts表达阳性率18.10%。GST-π表达、P-gp表达与年龄、性别、淋巴结转移、脉管癌栓及分化程度无关。Ts表达也与年龄、性别、淋巴结转移及分化程度无关,但与脉管癌栓有关(P<0.05)。P-gp与GST-π、Ts表达具有相关性(P<0.05)。结论:消化道肿瘤组织可表达P-gp与GST-π、Ts等耐药因子,三者表达具有相关性,GST-π、P-gp与Ts在消化道肿瘤组织中联合检测有重要的临床意义。Objective ： To investigate the relationship between the expression of GST - π, P - gp and Ts in gastro-intestinal carcinomas and the clinical pathological charaeterristic, to evaluate their clinical significance. Methods：All 127 cases of were examined by immunohistochemical technique （32 esophagus cancer,53 stomache cancer and 42 colorectal cancer）. Results ： The positive rates of GST - π, P - gp and Ts in gastrointestinal carcinomas were 80.95% ,44.86% ,18.10% respectively. The GST -π and P -gp were not related to age,gender,lymph node in- volvement, degree of differentiation and vessel cancer embolus. Ts was not related to age,gender,lymph node involve-ment, degree of differentiation. There was significant relationship between Ts expression and vessel cancer embolus（ P 〈 0.05 ）. There was significant relationship between P - gp, GST - π and Ts expression （ P 〈 0.05 ）. Conclusion ： There was significant relationship between P - gp, GST - π and Ts in gastrointestinal carcinomas.

关 键 词：谷胱苷肽-S-转移酶 P-糖蛋白 胸苷酸合成酶 消化道肿瘤 

分 类 号：R735[医药卫生—肿瘤]