中药干预治疗对晚期大肠癌生存期的影响  

Clinical study of traditional Chinese medicine on the survival time of advanced colorectal cancer

作　　者：吕仙梅 郑坚[2] 朱莹杰[2] 顾缨[2] 

机构地区：[1]浙江金华广福医院肿瘤内科,浙江金华321000 [2]上海中医药大学附属龙华医院肿瘤一科,上海200032

出　　处：《现代肿瘤医学》2012年第9期1911-1915,共5页Journal of Modern Oncology

摘　　要：目的:探讨中药干预治疗对晚期大肠癌生存期的作用。方法:采用非随机同期对照研究的方法,198例Ⅳ期大肠癌分别纳入中药组和非中药组,采用单因素分析的Kaplan-Meier法估算中位总生存期(OS),Log-rank法进行组间显著性检验,多因素分析Cox比例风险模型分析其独立预后因素。结果:198例Ⅳ期大肠癌死亡100例,占50.50%。Cox比例风险模型分析显示局部治疗(P=0.031)、中药治疗(P=0.019)是影响晚期大肠癌OS的独立性相关因素。非中药组中位OS为19.66个月,中药组中位OS为32.67个月。中药组中位OS较非中药组延长了13.01个月(P=0.025)。结论:中药干预治疗可延长晚期大肠癌OS。Objective：To examine the effects of traditional Chinese medicine on the overall survival of advanced colorectal cancer. Methods： A non-randomized concurrent control study was performed, 198 cases of advanced colorectal cancer were enrolled into a ＂traditional Chinese medicine＂ group and a ＂non - traditional Chinese medi-cine＂ group. Overall survival （OS） was estimated by method of Kaplan - Meier and Log - rank test was used to con-duct univariate analysis. Multivariate analysis was performed by Cox~ proportional hazard regression model. Results： Median survival was 19.66 months in 92 patients of ＂ traditional Chinese medicine＂ group versus 32.67 months in 106 patients of ＂non- traditional Chinese medicine＂ group（P = 0. 025 ）. The analysis of Cox＇s proportional hazard regression model showed that local treatment （P = 0. 031 ） and traditional Chinese medicine （P = 0. 019） were the independent related factors which influenced OS. Conclusion：Traditional Chinese medicine could be able to prolong OS of advanced colorectal cancer.

关 键 词：晚期大肠肿瘤 中药 生存期 

分 类 号：R735.34[医药卫生—肿瘤]